MicroRNA-Mediated Cancer Metastasis Regulation via Heterotypic Signals in the Microenvironment

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	MicroRNA-Mediated Cancer Metastasis Regulation via Heterotypic Signals in the Microenvironment
	Ma, HZ; Liang, CL; Wang, GX; Jia, SJ; Zhao, Q; Xiang, ZD; Li, Y; Cho, WC; Pestell, RG; Liang, L
刊名	CURRENT PHARMACEUTICAL BIOTECHNOLOGY
	2014
卷号	15 期号:5 页码:455-458
关键词	Cancer exosome metastasis microenvironment miRNA
ISSN号	1389-2010
文献子类	Article
英文摘要	MicroRNAs (miRNAs) are thought to regulate tumor progression and metastasis via direct interaction with target genes within cells. Emerging evidence has demonstrated the secretion of miRNAs into environment via cancer cell exosomes, called "exosomal shuttle small RNA". Microenvironmental miRNAs are important mediators of cell-to-cell communication, and they play important roles in regulating cancer metastasis. RNA analysis indicates enrichment of the miRNA population in cell-culturing medium. miRNA-conditioned medium is able to mediate the function of miRNAs in regulating cancer cell migration and invasion. Here we combine our recent work with literature discussing multiple mechanisms through which exosomal miRNAs regulate cancer cell migration, invasion and metastasis. We summarize a heterotypic signaling pathway by which miRNA regulates the cellular secretion and tumor microenvironment in control of breast cancer cell migration and invasion. In conclusion, exosomal miRNAs are able to regulate cancer metastasis via heterotypic signals in the microenvironment.
学科主题	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
出版地	SHARJAH
资助项目	国家自然科学基金项目 ; 国家重点基础研究发展计划以及国家重大科学研究计划（973计划）
项目编号	Natural Science Foundation of China [81172515] ; National Basic Research Program of China [2012CB966800] ; Science and Technology Commission of Shanghai Municipality [13JC1401702, 124119a7100] ; Dr. Ralph and Marian C. Falk Medical Research Trust ; [R01CA70896] ; [R01CA75503] ; [R01CA107382]
语种	英语
WOS记录号	WOS:000341916200005
资助机构	NSFC ; MOST
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125864]
专题	第一临床医学院_期刊论文
通讯作者	Yu, ZR (reprint author), Tongji Univ, East Hosp, Res Ctr Translat Med, Sch Med,Key Lab Arrhythmias,Minist Educ, 150 Jimo Rd, Shanghai 200120, Peoples R China.
推荐引用方式 GB/T 7714	Ma, HZ,Liang, CL,Wang, GX,et al. MicroRNA-Mediated Cancer Metastasis Regulation via Heterotypic Signals in the Microenvironment[J]. CURRENT PHARMACEUTICAL BIOTECHNOLOGY,2014,15(5):455-458.
APA	Ma, HZ.,Liang, CL.,Wang, GX.,Jia, SJ.,Zhao, Q.,...&Yu, ZR .(2014).MicroRNA-Mediated Cancer Metastasis Regulation via Heterotypic Signals in the Microenvironment.CURRENT PHARMACEUTICAL BIOTECHNOLOGY,15(5),455-458.
MLA	Ma, HZ,et al."MicroRNA-Mediated Cancer Metastasis Regulation via Heterotypic Signals in the Microenvironment".CURRENT PHARMACEUTICAL BIOTECHNOLOGY 15.5(2014):455-458.