Age-related bone turnover markers and osteoporotic risk in native Chinese women

doi:10.1186/1472-6823-14-8

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	Age-related bone turnover markers and osteoporotic risk in native Chinese women
	Wu, XY; Li, HL; Xie, H; Luo, XH; Peng, YQ; Yuan, LQ; Sheng, ZF; Dai, RC; Wu, XP; Liao, EY
刊名	BMC ENDOCRINE DISORDERS
	2014-01-22
卷号	14 页码:-
关键词	Bone turnover markers BMD T-scores Osteoporosis Osteoporotic risk Native Chinese women
ISSN号	1472-6823
DOI	10.1186/1472-6823-14-8
文献子类	Article
英文摘要	Background: The rate of bone turnover is closely related to osteoporosis risk. We investigated the correlation between bone turnover markers and BMD at various skeletal sites in healthy native Chinese women, and to study the effect of changes in the levels of bone turnover markers on the risk of osteoporosis. Methods: A cross-section study of 891 healthy Chinese women aged 20-80 years was conducted. The levels of serum osteocalcin (OC), bone-specific alkaline phosphatase (BAP), serum cross-linked N-terminal telopeptides of type I collagen (sNTX), cross-linked C-terminal telopeptides of type I collagen (sCTX), urinary NTX (uNTX), urinary CTX (uCTX) and total urinary deoxypyridinoline (uDPD) were determined. BMD at the posteroanterior spine and the hip was measured using DXA. Results: Pearson's correlation coefficient found significant negative correlation between bone turnover marker and BMD T-score at different skeletal sites (r = -0.08 to -0.52, all P = 0.038-0.000). After adjustments for age and body mass index, the partial correlation coefficients between the OC, BAP, sNTX, sCTX and uCTX, and the T-scores at various skeletal sites were still significant. After adjustment of height and weight, the correlation coefficients between most BTMs and PA lumbar spine BMD were also significant. Multiple linear regression analysis showed that bone turnover markers were negative determinants of T-scores. BAP and OC accounted for 33.1% and 7.8% of the variations in the T-scores of the PA spine, respectively. Serum OC, BAP, uDPD, and sNTX accounted for 0.4-21.9% of the variations in the femoral neck and total hip T-scores. The bone turnover marker levels were grouped as per quartile intervals, and the T-scores, osteoporosis prevalence and risk were found to markedly and increase with increase in bone turnover marker levels. Conclusions: This study clarified the relationship between bone turnover markers and osteoporosis risk in native Chinese women. Bone turnover marker levels were found to be important determinants of BMD T-scores. Furthermore, osteoporotic risk significantly increased with increase in the levels of bone turnover markers.
学科主题	Endocrinology & Metabolism
出版地	LONDON
项目编号	Ministry of Healthy P.R. of China [2004-468-50]
语种	英语
WOS记录号	WOS:000334622800002
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125850]
专题	第一临床医学院_期刊论文
通讯作者	Wu, XP (reprint author), Cent S Univ, Inst Metab & Endocrinol, Xiangya Hosp 2, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China.
推荐引用方式 GB/T 7714	Wu, XY,Li, HL,Xie, H,et al. Age-related bone turnover markers and osteoporotic risk in native Chinese women[J]. BMC ENDOCRINE DISORDERS,2014,14:-.
APA	Wu, XY.,Li, HL.,Xie, H.,Luo, XH.,Peng, YQ.,...&Wu, XP .(2014).Age-related bone turnover markers and osteoporotic risk in native Chinese women.BMC ENDOCRINE DISORDERS,14,-.
MLA	Wu, XY,et al."Age-related bone turnover markers and osteoporotic risk in native Chinese women".BMC ENDOCRINE DISORDERS 14(2014):-.