pH-sensitive sodium alginate/calcined hydrotalcite hybrid beads for controlled release of diclofenac sodium

doi:10.3109/03639045.2011.623702

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	pH-sensitive sodium alginate/calcined hydrotalcite hybrid beads for controlled release of diclofenac sodium
	Hua, SB; Yang, HX; Li, Q; Zhang, JP; Wang, AQ; Wang, AQ (reprint author), Chinese Acad Sci, Lanzhou Inst Chem Phys, Ctr Ecomat & Green Chem, Lanzhou 730000, Peoples R China.
刊名	DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
	2012-06
卷号	38 期号:6 页码:728-734
关键词	Bead alginate hydrotalcite drug release diclofenac sodium
ISSN号	0363-9045
DOI	10.3109/03639045.2011.623702
文献子类	Article
英文摘要	Objective: The aim of this study was to prepare pH-sensitive sodium alginate/calcined hydrotalcite (SA/CHT) hybrid bead with improved the burst release effect of the drug. Materials and methods: A series of pH-sensitive SA/CHT hybrid beads were prepared by using Ca2+ cross-linking in the presence of diclofenac sodium (DS) and SA. The structure and drug loading of the beads were characterized by Fourier transform infrared spectroscopy and X-ray diffraction. The swelling and the drug release of the fabricated beads were investigated by the pH of test medium and CHT content. Result: The formed positively charged hydrotalcite layers were adsorbed on the negatively charged SA polymer chains through electrostatic interaction and act as inorganic cross-linkers in the three-dimensional network. Compared to pure SA beads, the incorporation of CHT enhanced the drug encapsulation efficiency, improved the swelling behaviors and slowed the drug release from the hybrid beads. Discussion and conclusions: The electrostatic interaction between hydrotalcite and SA has restricted the movability of the SA polymer chains, and then slowed down swelling and dissolution rates in aqueous solutions. The results provided a simple method to moderate drug release and matrix degradation of the SA beads.
学科主题	Pharmacology & Pharmacy
出版地	LONDON
资助项目	国家自然科学基金项目
项目编号	National Natural Science Foundation of China [51003112] ; CAS
语种	英语
WOS记录号	WOS:000303327000010
资助机构	NSFC
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125744]
专题	第一临床医学院_期刊论文
通讯作者	Wang, AQ (reprint author), Chinese Acad Sci, Lanzhou Inst Chem Phys, Ctr Ecomat & Green Chem, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Hua, SB,Yang, HX,Li, Q,et al. pH-sensitive sodium alginate/calcined hydrotalcite hybrid beads for controlled release of diclofenac sodium[J]. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY,2012,38(6):728-734.
APA	Hua, SB,Yang, HX,Li, Q,Zhang, JP,Wang, AQ,&Wang, AQ .(2012).pH-sensitive sodium alginate/calcined hydrotalcite hybrid beads for controlled release of diclofenac sodium.DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY,38(6),728-734.
MLA	Hua, SB,et al."pH-sensitive sodium alginate/calcined hydrotalcite hybrid beads for controlled release of diclofenac sodium".DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY 38.6(2012):728-734.