Hepatitis B virus X protein (HBx) induces G2/M arrest and apoptosis through sustained activation of cyclin B1-CDK1 kinase

doi:10.3892/or_00000542

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	Hepatitis B virus X protein (HBx) induces G2/M arrest and apoptosis through sustained activation of cyclin B1-CDK1 kinase
	Cheng, P; Li, YH; Yang, LP; Wen, YJ; Shi, W; Mao, YQ; Chen, P; Lv, HM; Tang, QQ; Wei, YQ
刊名	ONCOLOGY REPORTS
	2009-11
卷号	22 期号:5 页码:1101-1107
关键词	HBV HBx hepatocellular carcinoma G2/M arrest apoptosis vascular endothelial cells
ISSN号	1021-335X
DOI	10.3892/or_00000542
文献子类	Article
英文摘要	Hepatitis B virus X protein (HBx) is a multifunctional regulatory protein that is known to be involved in viral proliferation, transcriptional activation and cell growth control. However, the actual role of HBx in cell growth control remains controversial. In this study, the impact of HBx on cell growth in vitro and in vivo was further investigated. HBx was able to inhibit the growth of hepatocellular carcinoma (HCC) cells and induce G2/M arrest in vitro. Moreover, unlike many other G2/M arrest mechanisms, HBx did not inhibit cyclin B1-CDK1 kinase activity, but it persistently activated the cyclin B1-CDK1 kinase. In vivo, HBx inhibited tumor cell growth and induced apoptosis as well as inhibited the growth of vascular endothelial cells. In conclusion, HBx induced G2/M arrest and apoptosis through sustained activation of cyclin B1-CDK1 kinase, and negatively regulated cell growth in vitro and in vivo.
学科主题	Oncology
出版地	ATHENS
资助项目	国家重点基础研究发展计划以及国家重大科学研究计划（973计划） ; 国家高技术研究发展计划（863计划）
项目编号	National Key Basic Research Program (973 Program) of China [2004CB518800, 2004CB518706] ; Hi-tech Research and Development Program (863 Program) of China [2006AA02Z488]
语种	英语
WOS记录号	WOS:000270573200020
资助机构	MOST
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125687]
专题	第一临床医学院_期刊论文
通讯作者	Wei, YQ (reprint author), Sichuan Univ, W China Med Sch, W China Hosp, State Key Lab Biotherapy, 1 Keyuan Rd 4,Gaopeng St,Technol Dev Zone, Chengdu 610041, Peoples R China.
推荐引用方式 GB/T 7714	Cheng, P,Li, YH,Yang, LP,et al. Hepatitis B virus X protein (HBx) induces G2/M arrest and apoptosis through sustained activation of cyclin B1-CDK1 kinase[J]. ONCOLOGY REPORTS,2009,22(5):1101-1107.
APA	Cheng, P.,Li, YH.,Yang, LP.,Wen, YJ.,Shi, W.,...&Wei, YQ .(2009).Hepatitis B virus X protein (HBx) induces G2/M arrest and apoptosis through sustained activation of cyclin B1-CDK1 kinase.ONCOLOGY REPORTS,22(5),1101-1107.
MLA	Cheng, P,et al."Hepatitis B virus X protein (HBx) induces G2/M arrest and apoptosis through sustained activation of cyclin B1-CDK1 kinase".ONCOLOGY REPORTS 22.5(2009):1101-1107.