Synthesis of hybrid 4-deoxypodophyllotoxin-5-fluorouracil compounds that inhibit cellular migration and induce cell cycle arrest

doi:10.1016/j.bmcl.2016.02.013

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	Synthesis of hybrid 4-deoxypodophyllotoxin-5-fluorouracil compounds that inhibit cellular migration and induce cell cycle arrest
	Guan, XW; Xu, XH; Feng, SL; Tang, ZB; Chen, SW; Hui, L; Chen, SW (reprint author), Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China.; Hui, L (reprint author), Lanzhou Mil Command, Ctr Med Expt, Gen Hosp, Lanzhou 730050, Peoples R China.; Hui, L (reprint author), Lanzhou Mil Command, Key Lab Stem Cells & Gene Drug Gansu Prov, Gen Hosp, Lanzhou 730050, Peoples R China.
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2016-03-15
卷号	26 期号:6 页码:1561-1566
关键词	Podophyllotoxin 5-Fluorouracil Cell cycle arrest Cell migration
ISSN号	0960-894X
DOI	10.1016/j.bmcl.2016.02.013
文献子类	Article
英文摘要	A series of deoxypodophyllotoxin-5-fluorouracil hybrid compounds were synthesized, and their cytotoxic activity was evaluated using four human cancer cell lines (HeLa, A549, HCT-8, and HepG2) and the human normal cell line WI-38. The synthesized compounds exhibited greater cytotoxic activity in tumor cells and reduced toxicity in the normal cell line compared with the anticancer drug VP-16 and 5-FU. Additionally, the most potent of these compounds-40-O-demethyl-4-deoxypodophyllotoxin-40-yl 4-((6-(2-(5-fluorouracil-yl) acetamido) hexyl) amino)-4-oxobutanoate (compound 22)-induced cell-cycle arrest in the G2/M phase by regulating levels of cdc2, cyclinB1, and p-cdc2 in A549 cells. Furthermore, compound 22 may inhibited the migration of A549 cells via down-regulation of MMP-9 and up-regulation of TIMP-1. (C) 2016 Elsevier Ltd. All rights reserved.
学科主题	Pharmacology & Pharmacy ; Chemistry
出版地	OXFORD
资助项目	国家自然科学基金项目
项目编号	National Natural Science Foundation of China [21372110, 81372177, 21302079]
语种	英语
WOS记录号	WOS:000371018800014
资助机构	NSFC
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179580]
专题	药学院_期刊论文
通讯作者	Chen, SW (reprint author), Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China.; Hui, L (reprint author), Lanzhou Mil Command, Ctr Med Expt, Gen Hosp, Lanzhou 730050, Peoples R China.; Hui, L (reprint author), Lanzhou Mil Command, Key Lab Stem Cells & Gene Drug Gansu Prov, Gen Hosp, Lanzhou 730050, Peoples R China.
推荐引用方式 GB/T 7714	Guan, XW,Xu, XH,Feng, SL,et al. Synthesis of hybrid 4-deoxypodophyllotoxin-5-fluorouracil compounds that inhibit cellular migration and induce cell cycle arrest[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016,26(6):1561-1566.
APA	Guan, XW.,Xu, XH.,Feng, SL.,Tang, ZB.,Chen, SW.,...&Hui, L .(2016).Synthesis of hybrid 4-deoxypodophyllotoxin-5-fluorouracil compounds that inhibit cellular migration and induce cell cycle arrest.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,26(6),1561-1566.
MLA	Guan, XW,et al."Synthesis of hybrid 4-deoxypodophyllotoxin-5-fluorouracil compounds that inhibit cellular migration and induce cell cycle arrest".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 26.6(2016):1561-1566.