Protective effects of the bioactive natural product N-trans-Caffeoyldopamine on hepatotoxicity induced by isoniazid and rifampicin

doi:10.1016/j.bmcl.2015.09.003

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	Protective effects of the bioactive natural product N-trans-Caffeoyldopamine on hepatotoxicity induced by isoniazid and rifampicin
	Wu, ZR; Bai, ZT; Sun, Y; Chen, P; Yang, ZG; Zhi, DJ; Li, Y; Wang, X; Du, JJ; Yang, R
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2015-11-15
卷号	25 期号:22 页码:5424-5426
关键词	N-trans-Caffeoyldopamine Antioxidant activity INH and RFP Hepatoprotective effect CYP2E1
ISSN号	0960-894X
DOI	10.1016/j.bmcl.2015.09.003
文献子类	Article
英文摘要	In our searching for novel antioxidants from natural sources, N-trans-Caffeoyldopamine which was from natural product was found to be a potential compound for its remarkable antioxidant activity. Isoniazid (INH) and Rifampicin (RFP) is widely used for the treatment of Tuberculosis (TB) as the first line drugs, have been known to be potentially hepatotoxic and may lead to drug-induced liver injury. Oxidative stress has been regarded as the major mechanism of the hepatotoxicity. Therefore, in this study, the possible protective effects of N-trans-Caffeoyldopamine was investigated in the hepatotoxicity caused by INH and RFP in rats. Results showed that serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels and hepatic malondialdehyde (MDA) content were reduced dramatically, and hepatic superoxide dismutase (SOD) activity and glutathione (GSH) content were restored remarkably by N-trans-Caffeoyldopamine co-administration, as compared to the INH-RFP treated rats (p < 0.01). Moreover, the histopathological damage of liver and the number of apoptotic hepatocytes were also significantly ameliorated by the treatment. It is therefore suggested that N-trans-Caffeoyldopamine can provide a definite protective effect against acute hepatic injury caused by INH and RFP in rats, which may mainly be associated with its antioxidative effect. Mechanisms studies indicated that it inhibited the lipid peroxidation through the cytochrome P450 2E1 (CYP2E1) downregulation. (C) 2015 Elsevier Ltd. All rights reserved.
学科主题	Pharmacology & Pharmacy ; Chemistry
出版地	OXFORD
资助项目	中央高校基本科研业务费专项资金 ; 甘肃省卫生厅资助项目
项目编号	Fundamental Research Funds for the Central Universities of China [lzujbky-2014-150, lzujbky-2015-57, lzujbky-2015-61] ; Foundation of The Health Industry research project of Gansu province [GWGL2014-45]
语种	英语
WOS记录号	WOS:000364535000083
资助机构	LZU ; GSPHD
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179566]
专题	药学院_期刊论文
通讯作者	Li, HY (reprint author), Lanzhou Univ, Inst Microbiol, Sch Life Sci, 222 Tian Shui South Rd, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Wu, ZR,Bai, ZT,Sun, Y,et al. Protective effects of the bioactive natural product N-trans-Caffeoyldopamine on hepatotoxicity induced by isoniazid and rifampicin[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2015,25(22):5424-5426.
APA	Wu, ZR.,Bai, ZT.,Sun, Y.,Chen, P.,Yang, ZG.,...&Li, HY .(2015).Protective effects of the bioactive natural product N-trans-Caffeoyldopamine on hepatotoxicity induced by isoniazid and rifampicin.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,25(22),5424-5426.
MLA	Wu, ZR,et al."Protective effects of the bioactive natural product N-trans-Caffeoyldopamine on hepatotoxicity induced by isoniazid and rifampicin".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 25.22(2015):5424-5426.