Activation of Intrinsic Apoptotic Signaling Pathway in A549 Cell by a Pectin Polysaccharide Isolated from Codonopsis pilosula and Its Selenized Derivative

doi:10.1080/07328303.2015.1095924

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	Activation of Intrinsic Apoptotic Signaling Pathway in A549 Cell by a Pectin Polysaccharide Isolated from Codonopsis pilosula and Its Selenized Derivative
	Chen, WX; Gou, YQ; Li, W; Zhang, P; Chen, JY; Wu, HM; Hu, FD; Cheng, WD; Hu, FD (reprint author), Lanzhou Univ, Sch Pharm, 199 Donggang Rd West, Lanzhou 730000, Peoples R China.
刊名	JOURNAL OF CARBOHYDRATE CHEMISTRY
	2015-10-13
卷号	34 期号:8 页码:475-489
关键词	CPP1b sCPP1b Apoptosis Intrinsic apoptotic pathway
ISSN号	0732-8303
DOI	10.1080/07328303.2015.1095924
文献子类	Article
英文摘要	sCPP1b is a selenized derivative of pectic polysaccharide (CPP1b) that is isolated from Wen-Codonopsis pilosula. In this study, A549 cells were used for in vitro studies on cytotoxicity, cell morphology, cell migration, cycle distribution, apoptosis, and expression of apoptosis-associated proteins after treatment with CPP1b and sCPP1b. Results show that sCPP1b and CPP1b could change cell morphology, suppress cell migration, induce cell apoptosis, and block the cell cycle. CPP1b and sCPP1b induced apoptosis on A549 cells through upregulation of caspase-3 and Bax and downregulation of Bcl-2 proteins. sCPP1b possessed stronger antitumor activity than CPP1b.
学科主题	Biochemistry & Molecular Biology ; Chemistry
出版地	PHILADELPHIA
资助项目	国家自然科学基金项目 ; 甘肃省自然科学基金计划
项目编号	Project of Science and Technology Agency of Gansu [1208RJZA211] ; Lanzhou [2012-2-67] ; Project of National Natural Science Foundation of China [81373806, 2014.1-2017.12.] ; Gansu province administration bureau of traditional Chinese medicine [GZK-2014-13]
语种	英语
WOS记录号	WOS:000366302500003
资助机构	NSFC ; GSSTD
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179562]
专题	药学院_期刊论文
通讯作者	Hu, FD (reprint author), Lanzhou Univ, Sch Pharm, 199 Donggang Rd West, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Chen, WX,Gou, YQ,Li, W,et al. Activation of Intrinsic Apoptotic Signaling Pathway in A549 Cell by a Pectin Polysaccharide Isolated from Codonopsis pilosula and Its Selenized Derivative[J]. JOURNAL OF CARBOHYDRATE CHEMISTRY,2015,34(8):475-489.
APA	Chen, WX.,Gou, YQ.,Li, W.,Zhang, P.,Chen, JY.,...&Hu, FD .(2015).Activation of Intrinsic Apoptotic Signaling Pathway in A549 Cell by a Pectin Polysaccharide Isolated from Codonopsis pilosula and Its Selenized Derivative.JOURNAL OF CARBOHYDRATE CHEMISTRY,34(8),475-489.
MLA	Chen, WX,et al."Activation of Intrinsic Apoptotic Signaling Pathway in A549 Cell by a Pectin Polysaccharide Isolated from Codonopsis pilosula and Its Selenized Derivative".JOURNAL OF CARBOHYDRATE CHEMISTRY 34.8(2015):475-489.