Effect of the tyrosinase inhibitor (S)-N-trans-feruloyloctopamine from garlic skin on tyrosinase gene expression and melanine accumulation in melanoma cells

doi:10.1016/j.bmcl.2015.02.028

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	Effect of the tyrosinase inhibitor (S)-N-trans-feruloyloctopamine from garlic skin on tyrosinase gene expression and melanine accumulation in melanoma cells
	Wu, Y; Wu, ZR; Chen, P; Yang-Li; Deng, WR; Wang, YQ; Li, HY; Li, HY (reprint author), Lanzhou Univ, Sch Pharmaceut, 222 Tian Shui South Rd, Lanzhou 730000, Peoples R China.
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2015-04-01
卷号	25 期号:7 页码:1476-1478
关键词	(S)-N-trans-Feruloyloctopamine Cytotoxicity Anti-melanogenic effect Tyrosinase expression
ISSN号	0960-894X
DOI	10.1016/j.bmcl.2015.02.028
文献子类	Article
英文摘要	In our searching for novel tyrosinase inhibitors from natural sources, (S)-N-trans-feruloyloctopamine isolated from garlic skin was found to be a potential mushroom tyrosinase inhibitor. Here, we examined the effects of the potential tyrosinase inhibitor in B16F10 cells on intracellular melanin contents, cytotoxicity, and the signaling mechanism involved in the expression of tyrosinase. The results showed the inhibitor displayed little or no cytotoxicity at all concentrations examined and decreased the relative melanin contents in a dose-dependent manner in the alpha-MSH-stimulated B16F10 cells. Real-time PCR and Western blot analysis showed that it inhibits melanogenesis signaling by down-regulates mRNA and protein expression levels of tyrosinase, which leads to a lower melanin contents. These results suggested that (S)-N-trans-feruloyloctopamine was an ideal tyrosinase inhibitor, and could be used in food and medical industry. (C) 2015 Elsevier Ltd. All rights reserved.
学科主题	Pharmacology & Pharmacy ; Chemistry
出版地	OXFORD
资助项目	中央高校基本科研业务费专项资金 ; 甘肃省杰出青年基金计划 ; 甘肃省技术研究与开发专项计划 ; 兰州市科技局资助项目
项目编号	Fundamental Research Funds for the Central Universities of China [lzujbky-2014-150] ; Gansu Province Science Foundation for Distinguished Young Scholars [1308RJDA014] ; Longyuan Support Project for Young Creative Talents [GANZUTONGZI [2014] no.4] ; Technology Program of Gansu Province [1207TCYA034] ; Technology Program of Lanzhou City [2013-4-115]
语种	英语
WOS记录号	WOS:000351688700023
资助机构	LZU ; GSSTD ; LZSTB
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179539]
专题	药学院_期刊论文
通讯作者	Li, HY (reprint author), Lanzhou Univ, Sch Pharmaceut, 222 Tian Shui South Rd, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Wu, Y,Wu, ZR,Chen, P,et al. Effect of the tyrosinase inhibitor (S)-N-trans-feruloyloctopamine from garlic skin on tyrosinase gene expression and melanine accumulation in melanoma cells[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2015,25(7):1476-1478.
APA	Wu, Y.,Wu, ZR.,Chen, P.,Yang-Li.,Deng, WR.,...&Li, HY .(2015).Effect of the tyrosinase inhibitor (S)-N-trans-feruloyloctopamine from garlic skin on tyrosinase gene expression and melanine accumulation in melanoma cells.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,25(7),1476-1478.
MLA	Wu, Y,et al."Effect of the tyrosinase inhibitor (S)-N-trans-feruloyloctopamine from garlic skin on tyrosinase gene expression and melanine accumulation in melanoma cells".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 25.7(2015):1476-1478.