Dihydroartemisinin loaded nanostructured lipid carriers (DHA-NLC): Evaluation of pharmacokinetics and tissue distribution after intravenous administration to rats

doi:10.1691/ph.2010.0082

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	Dihydroartemisinin loaded nanostructured lipid carriers (DHA-NLC): Evaluation of pharmacokinetics and tissue distribution after intravenous administration to rats
	Zhang, XY; Qiao, H; Liu, JP; Dong, HJ; Shen, CL; Ni, JM; Shi, YB; Xu, Y; Liu, JP (reprint author), China Pharmaceut Univ, Coll Pharm, Nanjing 210009, Peoples R China.
刊名	PHARMAZIE
	2010-09
卷号	65 期号:9 页码:670-678
ISSN号	0031-7144
DOI	10.1691/ph.2010.0082
文献子类	Article
英文摘要	A simple and rapid LC-MS/MS method was established for the determination of dihydroartemisinin (DHA) in plasma and tissues of rats. Sample preparation was achieved by liquid liquid extraction with aether and analysis was performed on LC-MS/MS in positive ion mode using electrospray ionization (ESI) as an interface. Target compounds were quantified in a single ion-monitoring (SIM) mode. DHA was monitored at m/z 267.1 and the internal standard finasteride at m/z 305.2. Chromatography was carried out using a Synergi fusion RP 80 column with a mixture of ethanol and 0.1% formic acid mixture (75:25) as the mobile phase. The pharmacokinetics and tissue distribution after intravenous administration of DHA in nanostructured lipid carrier (NLC) and in solution were then compared. The mean residence times (MRT) of the DHA-NLC was much longer than that of the DHA solution. In the tested organs, the AUC values of the DHA-NLC were higher than that of the DHA solution in liver, spleen, lung, brain and muscle, and lower than the DHA solution in heart and kidney. DHA-NLC prepared in this study is a promising sustained-release and drug-targeting system for antitumor drugs. It may also allow a reduction in dosage and a decrease in systemic toxicity.
学科主题	Pharmacology & Pharmacy ; Chemistry
出版地	ESCHBORN
语种	英语
WOS记录号	WOS:000282457400007
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/121883]
专题	药学院_期刊论文
通讯作者	Liu, JP (reprint author), China Pharmaceut Univ, Coll Pharm, Nanjing 210009, Peoples R China.
推荐引用方式 GB/T 7714	Zhang, XY,Qiao, H,Liu, JP,et al. Dihydroartemisinin loaded nanostructured lipid carriers (DHA-NLC): Evaluation of pharmacokinetics and tissue distribution after intravenous administration to rats[J]. PHARMAZIE,2010,65(9):670-678.
APA	Zhang, XY.,Qiao, H.,Liu, JP.,Dong, HJ.,Shen, CL.,...&Liu, JP .(2010).Dihydroartemisinin loaded nanostructured lipid carriers (DHA-NLC): Evaluation of pharmacokinetics and tissue distribution after intravenous administration to rats.PHARMAZIE,65(9),670-678.
MLA	Zhang, XY,et al."Dihydroartemisinin loaded nanostructured lipid carriers (DHA-NLC): Evaluation of pharmacokinetics and tissue distribution after intravenous administration to rats".PHARMAZIE 65.9(2010):670-678.