Impact of probable interaction of low temperature and ambient fine particulate matter on the function of rats alveolar macrophages

doi:10.1016/j.etap.2016.12.011

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	Impact of probable interaction of low temperature and ambient fine particulate matter on the function of rats alveolar macrophages
	Luo, B; Liu, JT; Fei, GQ; Han, T; Zhang, K; Wang, LN; Shi, HX; Zhang, L; Ruan, Y; Niu, JP
刊名	ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
	2017-01
卷号	49 页码:172-178
关键词	Lower temperature Ambient PM2.5 Phagocytosis function Rat alveolar macrophages Inflammatory factors Interactive effects
ISSN号	1382-6689
DOI	10.1016/j.etap.2016.12.011
文献子类	Article
英文摘要	The present study aimed to explore the probable interaction of low temperature and ambient fine particulate matter (PM2.5) on rat alveolar macrophages (AMs). AMs were separated from rat BALF and exposed to PM2.5 (0, 25, 50, 100 mu g/ml) under different temperature (18, 24, 30, 37 degrees C) for 8 h. Results indicated that viability and phagocytosis function of AMs decreased with the decline of temperature and the rise of PM2.5 dose, and the strongest toxicity was shown in the highest PM2.5 (100 mu g/ml) exposure group at 18 C. Both PM2.5 and lower temperature increased the releasing of tumor necrosis factor alpha (TNF alpha), macrophage inflammatory protein la (MIP-1 alpha) and interleukin-6 (IL-6), while significant interaction was only found in MIP-1 alpha production. No obvious change was found in granulocyte-macrophage colony stimulating factor (GM-CSF) detection. These results indicated that both the two factors are harmful to rat AMs and lower temperature could increase the toxicity of PM2.5 on the AMs. (C) 2016 Elsevier B.V. All rights reserved.
学科主题	Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology
出版地	AMSTERDAM
资助项目	国家自然科学基金项目 ; 中央高校基本科研业务费专项资金
项目编号	National Natural Science Foundation of China [41405108] ; Fundamental Research Funds for the Central Universities, Lanzhou university, China [lzujbky-2015-191]
语种	英语
WOS记录号	WOS:000393246600023
资助机构	NSFC ; LZU
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/189115]
专题	公共卫生学院_期刊论文
通讯作者	Luo, B (reprint author), Lanzhou Univ, Inst Occupat Hlth & Environm Hlth, Sch Publ Hlth, Lanzhou 730000, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Luo, B,Liu, JT,Fei, GQ,et al. Impact of probable interaction of low temperature and ambient fine particulate matter on the function of rats alveolar macrophages[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2017,49:172-178.
APA	Luo, B.,Liu, JT.,Fei, GQ.,Han, T.,Zhang, K.,...&Luo, B .(2017).Impact of probable interaction of low temperature and ambient fine particulate matter on the function of rats alveolar macrophages.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,49,172-178.
MLA	Luo, B,et al."Impact of probable interaction of low temperature and ambient fine particulate matter on the function of rats alveolar macrophages".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 49(2017):172-178.