Metabolic syndrome and the risk of breast cancer among postmenopausal women in north-west China

doi:10.3109/13697137.2015.1071346

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	Metabolic syndrome and the risk of breast cancer among postmenopausal women in north-west China
	Wang, M; Cheng, N; Zheng, S; Wang, D; Hu, X; Ren, X; Pei, H; Ma, H; Mu, H; Bai, Y
刊名	CLIMACTERIC
	2015-11-02
卷号	18 期号:6 页码:852-858
关键词	BREAST CANCER METABOLIC SYNDROME POSTMENOPAUSAL CASE-CONTROL STUDY CHINA
ISSN号	1369-7137
DOI	10.3109/13697137.2015.1071346
文献子类	Article
英文摘要	ObjectiveTo determine whether metabolic syndrome (MetS) and its components are risk factors for breast cancer among postmenopausal women in China.MethodsBased on the baseline data of the Jinchang Cohort, a case-control study was carried out among postmenopausal women, including 43 cases and 86 controls. Both MetS and its components were evaluated. Odds ratios and 95% confidence intervals (CI) for the association were estimated by conditional logistic regression analysis.ResultsThe odds ratio of postmenopausal breast cancer was 3.505 (95% CI 1.282-9.583) for MetS, 3.016 (95% CI 1.044-8.715) for body mass index (BMI)25kg/m(2), and 3.191 (95% CI 1.253-8.125) for dyslipidemia. There was no significant association between postmenopausal breast cancer and hypertension as well as diabetes. Women with four metabolic factors showed greater risk for postmenopausal breast cancer (p(trend)<0.05). Dyslipidemia and BMI25kg/m(2) showed most significant interaction on breast cancer (odds ratio=11.359; 95% CI 2.663-48.450). With BMI25kg/m(2), the interaction of dyslipidemia and other metabolic factors on breast cancer was higher than that without BMI25kg/m(2).ConclusionThis case-control study suggested that MetS was associated with an elevated risk of breast cancer among postmenopausal women in north-west China. Overweight and dyslipidemia had the strongest adverse effects on postmenopausal breast cancer.
学科主题	Obstetrics & Gynecology
出版地	ABINGDON
资助项目	中央高校基本科研业务费专项资金
项目编号	Fundamental Research Funds for the Central Universities [lzujbky-2014-154]
语种	英语
WOS记录号	WOS:000365614000017
资助机构	LZU
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179616]
专题	公共卫生学院_期刊论文
通讯作者	Bai, Y (reprint author), Lanzhou Univ, Sch Publ Hlth, Lanzhou 730000, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Wang, M,Cheng, N,Zheng, S,et al. Metabolic syndrome and the risk of breast cancer among postmenopausal women in north-west China[J]. CLIMACTERIC,2015,18(6):852-858.
APA	Wang, M.,Cheng, N.,Zheng, S.,Wang, D.,Hu, X.,...&Bai, Y .(2015).Metabolic syndrome and the risk of breast cancer among postmenopausal women in north-west China.CLIMACTERIC,18(6),852-858.
MLA	Wang, M,et al."Metabolic syndrome and the risk of breast cancer among postmenopausal women in north-west China".CLIMACTERIC 18.6(2015):852-858.