Discovery of biomarkers for oxidative stress based on cellular metabolomics

doi:10.3109/1354750X.2016.1153720

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	Discovery of biomarkers for oxidative stress based on cellular metabolomics
	Wang, NL; Wei, JT; Liu, YW; Pei, D; Hu, QP; Wang, Y; Di, DL; Liu, YW (reprint author), Lanzhou Univ, Sch Publ Hlth, Inst Nutr & Food Hyg, 199 Donggang West Rd, Lanzhou 730000, Peoples R China.; Wei, JT (reprint author), Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, 18 Tianshui Middle Rd, Lanzhou 730000, Peoples R China.; Wei, JT (reprint author), Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, 18 Tianshui Middle Rd, Lanzhou 730000, Peoples R China.
刊名	BIOMARKERS
	2016
卷号	21 期号:5 页码:449-457
关键词	Biomarkers metabolomics oxidative stress
ISSN号	1354-750X
DOI	10.3109/1354750X.2016.1153720
文献子类	Article
英文摘要	Oxidative stress has a close relationship with various pathologic physiology phenomena and the potential biomarkers of oxidative stress may provide evidence for clinical diagnosis or disease prevention. Metabolomics was employed to identify the potential biomarkers of oxidative stress. High-performance liquid chromatography-diode array detector, mass spectrometry and partial least squares discriminate analysis were used in this study. The 10, 15 and 13 metabolites were considered to discriminate the model group, vitamin E-treated group and L-glutathione-treated group, respectively. Some of them have been identified, namely, malic acid, vitamin C, reduced glutathione and tryptophan. Identification of other potential biomarkers should be conducted and their physiological significance also needs to be elaborated.
学科主题	Biotechnology & Applied Microbiology ; Toxicology
出版地	ABINGDON
资助项目	国家自然科学基金项目 ; 国家高技术研究发展计划（863计划） ; 甘肃省青年科技基金计划
项目编号	National Natural Sciences Foundation of China [21175142, 21505143] ; National High Technology Research and Development Program of China [2014AA022203] ; Science Foundation of Gansu Province [1308RJYA077]
语种	英语
WOS记录号	WOS:000379348200009
资助机构	NSFC ; MOST ; GSSTD
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179603]
专题	公共卫生学院_期刊论文
通讯作者	Liu, YW (reprint author), Lanzhou Univ, Sch Publ Hlth, Inst Nutr & Food Hyg, 199 Donggang West Rd, Lanzhou 730000, Peoples R China.; Wei, JT (reprint author), Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, 18 Tianshui Middle Rd, Lanzhou 730000, Peoples R China.; Wei, JT (reprint author), Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, 18 Tianshui Middle Rd, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Wang, NL,Wei, JT,Liu, YW,et al. Discovery of biomarkers for oxidative stress based on cellular metabolomics[J]. BIOMARKERS,2016,21(5):449-457.
APA	Wang, NL.,Wei, JT.,Liu, YW.,Pei, D.,Hu, QP.,...&Wei, JT .(2016).Discovery of biomarkers for oxidative stress based on cellular metabolomics.BIOMARKERS,21(5),449-457.
MLA	Wang, NL,et al."Discovery of biomarkers for oxidative stress based on cellular metabolomics".BIOMARKERS 21.5(2016):449-457.