Neuropeptide S ameliorates olfactory spatial memory impairment induced by scopolamine and MK801 through activation of cognate receptor-expressing neurons in the subiculum complex

doi:10.1007/s00429-015-1103-y

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	Neuropeptide S ameliorates olfactory spatial memory impairment induced by scopolamine and MK801 through activation of cognate receptor-expressing neurons in the subiculum complex
	Shao, YF; Wang, C; Xie, JF; Kong, XP; Xin, L; Dong, CY; Li, J; Ren, WT; Hou, YP; Hou, YP (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Sch Basic Med Sci, Dept Neurosci, 199 Donggang Xi Rd, Lanzhou 730000, Peoples R China.
刊名	BRAIN STRUCTURE & FUNCTION
	2016-07
卷号	221 期号:6 页码:3327-3336
关键词	Neuropeptide S (NPS) Neuropeptide S receptor (NPSR) Olfactory spatial memory Subiculum complex Muscarinic cholinergic receptor N-methyl-D-aspartate receptor Antagonist c-Fos
ISSN号	1863-2653
DOI	10.1007/s00429-015-1103-y
文献子类	Article
英文摘要	Our previous studies have demonstrated that neuropeptide S (NPS), via selective activation of the neurons bearing NPS receptor (NPSR) in the olfactory cortex, facilitates olfactory function. High level expression of NPSR mRNA in the subiculum complex of hippocampal formation suggests that NPS-NPSR system might be involved in the regulation of olfactory spatial memory. The present study was undertaken to investigate effects of NPS on the scopolamine-or MK801-induced impairment of olfactory spatial memory using computer-assisted 4-hole-board spatial memory test, and by monitoring Fos expression in the subiculum complex in mice. In addition, dual-immunofluorescence microscopy was employed to identify NPS-induced Fos-immunereactive (-ir) neurons that also bear NPSR. Intracerebroventricular administration of NPS (0.5 nmol) significantly increased the number of visits to switched odorants in recall trial in mice suffering from odor-discriminating inability induced by scopolamine, a selective muscarinic cholinergic receptor antagonist, or MK801, a N-methyl-D-aspartate receptor antagonist, after training trials. The improvement of olfactory spatial memory by NPS was abolished by the NPSR antagonist [D-Val(5)] NPS (40 nmol). Ex vivo c-Fos and NPSR immunohistochemistry revealed that, as compared with vehicle-treated mice, NPS markedly enhanced Fos expression in the subiculum complex encompassing the subiculum (S), presubiculum (PrS) and parasubiculum (PaS). The percentages of Fos-ir neurons that also express NPSR were 91.3, 86.5 and 90.0 % in the S, PrS and PaS, respectively. The present findings demonstrate that NPS, via selective activation of the neurons bearing NPSR in the subiculum complex, ameliorates olfactory spatial memory impairment induced by scopolamine and MK801 in mice.
学科主题	Anatomy & Morphology ; Neurosciences & Neurology
出版地	HEIDELBERG
语种	英语
WOS记录号	WOS:000382684300027
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179126]
专题	基础医学院_期刊论文
通讯作者	Hou, YP (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Sch Basic Med Sci, Dept Neurosci, 199 Donggang Xi Rd, Lanzhou 730000, Peoples R China.; Hou, YP (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Sch Basic Med Sci, Dept Anat, 199 Donggang Xi Rd, Lanzhou 730000, Peoples R China.; Hou, YP (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Sch Basic Med Sci, Dept Histol, 199 Donggang Xi Rd, Lanzhou 730000, Peoples R China.; Hou, YP (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Sch Basic Med Sci, Dept Embryol, 199 Donggang Xi Rd, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Shao, YF,Wang, C,Xie, JF,et al. Neuropeptide S ameliorates olfactory spatial memory impairment induced by scopolamine and MK801 through activation of cognate receptor-expressing neurons in the subiculum complex[J]. BRAIN STRUCTURE & FUNCTION,2016,221(6):3327-3336.
APA	Shao, YF.,Wang, C.,Xie, JF.,Kong, XP.,Xin, L.,...&Hou, YP .(2016).Neuropeptide S ameliorates olfactory spatial memory impairment induced by scopolamine and MK801 through activation of cognate receptor-expressing neurons in the subiculum complex.BRAIN STRUCTURE & FUNCTION,221(6),3327-3336.
MLA	Shao, YF,et al."Neuropeptide S ameliorates olfactory spatial memory impairment induced by scopolamine and MK801 through activation of cognate receptor-expressing neurons in the subiculum complex".BRAIN STRUCTURE & FUNCTION 221.6(2016):3327-3336.