Effects of neuropeptide FF and related peptides on the antinociceptive activities of VD-hemopressin(alpha) in naive and cannabinoid-tolerant mice

doi:10.1016/j.ejphar.2015.10.016

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	Effects of neuropeptide FF and related peptides on the antinociceptive activities of VD-hemopressin(alpha) in naive and cannabinoid-tolerant mice
	Pan, JX; Wang, ZL; Li, N; Zhang, N; Wang, P; Tang, HH; Zhang, T; Yu, HP; Zhang, R; Zheng, T
刊名	EUROPEAN JOURNAL OF PHARMACOLOGY
	2015-11-15
卷号	767 页码:119-125
关键词	Cannabinoids Neuropeptide FF VD-hemopressin(alpha) Antinociception Tolerance Mice
ISSN号	0014-2999
DOI	10.1016/j.ejphar.2015.10.016
文献子类	Article
英文摘要	Neuropeptide FF (NPFF) system has recently been reported to modulate cannabinoid-induced antinociception. The aim of the present study was to further investigate the roles of NPFF system in the antinociceptive effects induced by intracerebroventricular (i.c.v.) administration of mouse VD-hemopressin(alpha), a novel endogenous agonist of cannabinoid CB1 receptor, in naive and VD-hemopressin(alpha)tolerant mice. The effects of NPFF system on the antinociception induced by VD-hemopressin(alpha) were investigated in the radiant heat tail-flick test in naive mice and VD-hemopressin(alpha)-tolerant mice. The cannabinoid-tolerant mice were produced by given daily injections of VD-hemopressin(alpha) (20 nmol, i.c.v.) for 5 days and the antinociception was measured on day 6. In naive mice, intracerebroventricular injection of NPFF dose-dependently attenuated central analgesia of VD-hemopressin(alpha). In contrast, neuropeptide VF (NPVF) and D.NP(N-Me)AFLFQPQRF-NH2 (dNPA), two highly selective agonists for Neuropeptide FF1 and Neuropeptide FF2 receptors, enhanced VD-hemopressin(alpha)-induced antinociception in a dose-dependent manner. In addition, the VD-hemopressin(alpha)-modulating activities of NPFF and related peptides were antagonized by the Neuropeptide FF receptors selective antagonist 1-adamantanecarbonyl-RF-NH2 (RF9). In VD-hemopressin(oc)-tolerant mice, NPFF failed to modify VD-hemopressin(oc)-induced antinociception. However, both neuropeptide VF and dNPA dose-dependently potentiated the antinociception of VD-hemopressin(oc) and these cannabinoid-potentiating effects were reduced by RF9. The present works support the cannabinoid-modulating character of NPFF system in naive and cannabinoid-tolerant mice. In addition, the data suggest that a chronic cannabinoid treatment modifies the pharmacological profiles of NPFF, but not the cannabinoid-potentiating effects of neuropeptide VF and dNPA. (C) 2015 Elsevier B.V. All rights reserved.
学科主题	Pharmacology & Pharmacy
出版地	AMSTERDAM
资助项目	国家自然科学基金项目 ; 新世纪优秀人才支持计划 ; 中央高校基本科研业务费专项资金 ; 甘肃省青年科技基金计划
项目编号	National Natural Science Foundation of China [81273355, 81473095] ; Program for New Century Excellent Talents in University [NCET-13-0257] ; Natural Science Foundation of Gansu Province, China [1208RJYA001] ; Fundamental Research Funds for the Central Universities [1zujbky-2014-141]
语种	英语
WOS记录号	WOS:000364839500015
资助机构	NSFC ; MOE ; LZU ; GSSTD
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179077]
专题	基础医学院_期刊论文
通讯作者	Fang, Q (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, 199 Donggang West Rd, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Pan, JX,Wang, ZL,Li, N,et al. Effects of neuropeptide FF and related peptides on the antinociceptive activities of VD-hemopressin(alpha) in naive and cannabinoid-tolerant mice[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2015,767:119-125.
APA	Pan, JX.,Wang, ZL.,Li, N.,Zhang, N.,Wang, P.,...&Fang, Q .(2015).Effects of neuropeptide FF and related peptides on the antinociceptive activities of VD-hemopressin(alpha) in naive and cannabinoid-tolerant mice.EUROPEAN JOURNAL OF PHARMACOLOGY,767,119-125.
MLA	Pan, JX,et al."Effects of neuropeptide FF and related peptides on the antinociceptive activities of VD-hemopressin(alpha) in naive and cannabinoid-tolerant mice".EUROPEAN JOURNAL OF PHARMACOLOGY 767(2015):119-125.