Catalytic Asymmetric [3+2] Cyclization Reactions of 3-lsothiocyanato Oxindoles and Alkynyl Ketones Via an in Situ Generated Magnesium Catalyst

doi:10.1021/acs.orglett.3b02052

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	Catalytic Asymmetric [3+2] Cyclization Reactions of 3-lsothiocyanato Oxindoles and Alkynyl Ketones Via an in Situ Generated Magnesium Catalyst
	Wang, LQ; Yang, DX; Li, D; Liu, XH; Zhao, Q; Zhu, RR; Zhang, BZ; Wang, R; Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Sch Life Sci, Lanzhou 730000, Peoples R China.
刊名	ORGANIC LETTERS
	2015-09-04
卷号	17 期号:17 页码:4260-4263
ISSN号	1523-7060
DOI	10.1021/acs.orglett.3b02052
文献子类	Article
英文摘要	A highly enantioselective formal [3 + 2] cycloaddition reaction between 3-isothiocyanato oxindoles and alkynyl ketones is reported for the first time. An oxazoline OH type chiral ligand derived from o-hydroxyphenylacetic acid is employed to generate an effective magnesium catalyst in the current cyclization reaction and give serials of chiral spirocodndoles with good chemical yields and enantioselectivities.
学科主题	Chemistry
出版地	WASHINGTON
资助项目	国家自然科学基金项目 ; 国家科技重大专项 ; 长江学者和创新团队发展计划 ; 甘肃省创新研究群体计划
项目编号	NSFC [91213302, 91413107, 81473095, 21432003] ; National S&T Major Project of China [2012ZX09504001-003] ; Program for Chang-jiang Scholars and Innovative Research Team in University [PCSIRT: IRT1137] ; Innovation Group of Gansu Province [1210RJIA002]
语种	英语
WOS记录号	WOS:000361087200035
资助机构	NSFC ; MOST ; MOE ; GSSTD
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179060]
专题	基础医学院_期刊论文
通讯作者	Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Sch Life Sci, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Wang, LQ,Yang, DX,Li, D,et al. Catalytic Asymmetric [3+2] Cyclization Reactions of 3-lsothiocyanato Oxindoles and Alkynyl Ketones Via an in Situ Generated Magnesium Catalyst[J]. ORGANIC LETTERS,2015,17(17):4260-4263.
APA	Wang, LQ.,Yang, DX.,Li, D.,Liu, XH.,Zhao, Q.,...&Wang, R .(2015).Catalytic Asymmetric [3+2] Cyclization Reactions of 3-lsothiocyanato Oxindoles and Alkynyl Ketones Via an in Situ Generated Magnesium Catalyst.ORGANIC LETTERS,17(17),4260-4263.
MLA	Wang, LQ,et al."Catalytic Asymmetric [3+2] Cyclization Reactions of 3-lsothiocyanato Oxindoles and Alkynyl Ketones Via an in Situ Generated Magnesium Catalyst".ORGANIC LETTERS 17.17(2015):4260-4263.