The role of apelin-13 in novel object recognition memory

doi:10.1016/j.peptides.2014.10.003

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	The role of apelin-13 in novel object recognition memory
	Han, RW; Xu, HJ; Zhang, RS; Wang, R; Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, 222 Tian Shui South Rd, Lanzhou 730000, Peoples R China.
刊名	PEPTIDES
	2014-12
卷号	62 页码:155-158
关键词	Apelin-13 APJ Object recognition Short-term memory Long-term memory
ISSN号	0196-9781
DOI	10.1016/j.peptides.2014.10.003
文献子类	Article
英文摘要	Apelin and its receptor APJ (apelin receptor) are prominently expressed in brain regions involved in learning and memory. However, the role of apelin in cognition was largely unclear. Here, the role of apelin-13 in memory processes was investigated in mice novel object recognition task. Post-training injection of apelin-13 (0.3 and 1 nmol) dose-dependently impaired short-term memory (STM), however, pre-training infusion of apelin-13 (1 nmol) did not affect STM, suggesting apelin-13 blocks formation but not acquisition of STM. Apelin-13 (1 nmol) administered immediately, 30, 60 or 120 min post-training impaired long-term memory (LTM) in a time-dependent manner (30 min), however, both pre-training and pre-test infusion of apelin-13 (1 nmol) did not affect LTM, suggesting apelin-13 impaired consolidation but not acquisition and recall of LTM. Taken together, for the first time, our results indicate that apelin-13 blocks STM formation and LTM consolidation in novel object recognition task. (C) 2014 Elsevier Inc. All rights reserved.
学科主题	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
出版地	NEW YORK
资助项目	国家自然科学基金项目 ; 国家科技重大专项
项目编号	National Natural Science Foundation of China [91213302, 21272102, 21432003, 81473095, 81460546] ; Key National Science and Technology Program "Major New Drug Development" of the Ministry of Science and Technology of China [2012ZX09504001-003] ; Natural Science Foundation of Jiangxi Province [20142BAB215018] ; Foundation of Jiangxi Provincial Education [GJJ14216]
语种	英语
WOS记录号	WOS:000345614700014
资助机构	NSFC ; MOST
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/121745]
专题	基础医学院_期刊论文
通讯作者	Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, 222 Tian Shui South Rd, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Han, RW,Xu, HJ,Zhang, RS,et al. The role of apelin-13 in novel object recognition memory[J]. PEPTIDES,2014,62:155-158.
APA	Han, RW,Xu, HJ,Zhang, RS,Wang, R,&Wang, R .(2014).The role of apelin-13 in novel object recognition memory.PEPTIDES,62,155-158.
MLA	Han, RW,et al."The role of apelin-13 in novel object recognition memory".PEPTIDES 62(2014):155-158.