Radix Hedysari polysaccharide suppresses lipid metabolism dysfunction in a rat model of non-alcoholic fatty liver disease via adenosine monophosphate-activated protein kinase pathway activation

doi:10.3892/mmr.2014.2327

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	Radix Hedysari polysaccharide suppresses lipid metabolism dysfunction in a rat model of non-alcoholic fatty liver disease via adenosine monophosphate-activated protein kinase pathway activation
	Sun, WM; Wang, YP; Duan, YQ; Shang, HX; Cheng, WD; Cheng, WD (reprint author), Lanzhou Univ, Sch Basic Med Sci, Inst Integrated Chinese & Western Med, 199 Dong Gang West Rd, Lanzhou 730000, Gansu, Peoples R China.
刊名	MOLECULAR MEDICINE REPORTS
	2014-09
卷号	10 期号:3 页码:1237-1244
关键词	Radix Hedysari polysaccharide lipid metabolism non-alcoholic fatty liver disease adenosine monophosphate-activated protein kinase pathway
ISSN号	1791-2997
DOI	10.3892/mmr.2014.2327
文献子类	Article
英文摘要	Oxidative stress and excess hepatic lipid accumulation contribute to non-alcoholic fatty liver disease. Radix Hedysari polysaccharides (RHP) have attracted interest due to their antioxidant properties and immunomodulatory effects. However, the effect of RHP on hepatic lipid metabolism remains to be elucidated. In the present study, the response of Sprague-Dawley rat livers to a high-fat diet and RHP treatment was investigated by evaluating body weight, liver histology, hepatic lipid content, adenosine monophosphate-activated protein kinase (AMPK) activity and lipid metabolism gene transcriptional profiles. The present study demonstrated that RHP ameliorated lipid metabolism disorders, regulated hepatic lipid content, improved liver inflammation and damage, activated AMPK via phosphorylation, upregulated peroxisome proliferator-activated receptor a and downregulated the mRNA expression of sterol regulatory element binding protein-lc in rat livers, which reduced lipogenesis and increased lipolysis. Taken together, these results suggested that RHP effectively ameliorates lipid metabolism disorders in rat livers; thus, RHP may be a potential therapeutic agent in the prevention of hepatic steatosis
学科主题	Oncology ; Research & Experimental Medicine
出版地	ATHENS
资助项目	中央高校基本科研业务费专项资金
项目编号	Fundamental Research Funds for the Central Universities [lzujbky-2013-159] ; Scientific Research Project of Traditional Chinese Medicine Administration in Gansu Province [GZK-2012-65]
语种	英语
WOS记录号	WOS:000340854500008
资助机构	LZU
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/121718]
专题	基础医学院_期刊论文
通讯作者	Cheng, WD (reprint author), Lanzhou Univ, Sch Basic Med Sci, Inst Integrated Chinese & Western Med, 199 Dong Gang West Rd, Lanzhou 730000, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Sun, WM,Wang, YP,Duan, YQ,et al. Radix Hedysari polysaccharide suppresses lipid metabolism dysfunction in a rat model of non-alcoholic fatty liver disease via adenosine monophosphate-activated protein kinase pathway activation[J]. MOLECULAR MEDICINE REPORTS,2014,10(3):1237-1244.
APA	Sun, WM,Wang, YP,Duan, YQ,Shang, HX,Cheng, WD,&Cheng, WD .(2014).Radix Hedysari polysaccharide suppresses lipid metabolism dysfunction in a rat model of non-alcoholic fatty liver disease via adenosine monophosphate-activated protein kinase pathway activation.MOLECULAR MEDICINE REPORTS,10(3),1237-1244.
MLA	Sun, WM,et al."Radix Hedysari polysaccharide suppresses lipid metabolism dysfunction in a rat model of non-alcoholic fatty liver disease via adenosine monophosphate-activated protein kinase pathway activation".MOLECULAR MEDICINE REPORTS 10.3(2014):1237-1244.