Whole Brain Radiotherapy Combined with Stereotactic Radiotherapy Versus Stereotactic Radiotherapy Alone for Brain Metastases: a Meta-analysis

doi:10.7314/APJCP.2014.15.2.911

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	Whole Brain Radiotherapy Combined with Stereotactic Radiotherapy Versus Stereotactic Radiotherapy Alone for Brain Metastases: a Meta-analysis
	Duan, L; Zeng, R; Yang, KH; Tian, JH; Wu, XL; Dai, Q; Niu, XD; Ma, DW; Yang, KH (reprint author), Lanzhou Univ, Evidence Based Med Ctr, Lanzhou 730000, Peoples R China.
刊名	ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
	2014
卷号	15 期号:2 页码:911-915
关键词	Brain metastases whole brain radiation stereotactic radiotherapy meta-analysis
ISSN号	1513-7368
DOI	10.7314/APJCP.2014.15.2.911
文献子类	Article
英文摘要	Aim: This study was to evaluate the effect of whole brain radiation (WBRT) combined with stereotactic radiotherapy (SRS) versus stereotactic radiotherapy alone for patients with brain metastases using a meta-analysis. Materials and Methods: We searched PubMed, EMBASE, Cochrane Library from their inception up to October 2013. Randomized controlled trials involving whole brain radiation combined with stereotactic radiotherapy versus stereotactic radiotherapy alone for brain metastases were included. Statistical analyses were performed using RevMan5.2 software. Results: Four randomized controlled trials including 903 patients were included. The meta-analysis showed statistically significant lowering of the local recurrence rate (OR=0.29, 95% CI: 0.17 similar to 0.49), new brain metastasis rate (OR=0.45, 95% CI: 0.28 similar to 0.71) and symptomatic late neurologic radiation toxicity rate (OR=3.92, 95% CI: 1.37 similar to 11.20) in the combined group. No statistically significant difference existed in the 1-year survival rate (OR=0.78, 95% CI: 0.60 similar to 1.03). Conclusions: The results indicate that whole brain radiotherapy combined with stereotactic radiotherapy has advantages in local recurrence and new brain metastasis rates, but stereotactic radiotherapy alone is associated with better neurological function. However, as the samples included were not large, more high-quality, large-sample size studies are necessary for confirmation.
学科主题	Oncology
出版地	GYEONGGI-DO
语种	英语
WOS记录号	WOS:000332517500065
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/121684]
专题	基础医学院_期刊论文
通讯作者	Yang, KH (reprint author), Lanzhou Univ, Evidence Based Med Ctr, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Duan, L,Zeng, R,Yang, KH,et al. Whole Brain Radiotherapy Combined with Stereotactic Radiotherapy Versus Stereotactic Radiotherapy Alone for Brain Metastases: a Meta-analysis[J]. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,2014,15(2):911-915.
APA	Duan, L.,Zeng, R.,Yang, KH.,Tian, JH.,Wu, XL.,...&Yang, KH .(2014).Whole Brain Radiotherapy Combined with Stereotactic Radiotherapy Versus Stereotactic Radiotherapy Alone for Brain Metastases: a Meta-analysis.ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,15(2),911-915.
MLA	Duan, L,et al."Whole Brain Radiotherapy Combined with Stereotactic Radiotherapy Versus Stereotactic Radiotherapy Alone for Brain Metastases: a Meta-analysis".ASIAN PACIFIC JOURNAL OF CANCER PREVENTION 15.2(2014):911-915.