The stimulative effects of endogenous opioids on endothelial cell proliferation, migration and angiogenesis in vitro

doi:10.1016/j.ejphar.2009.11.035

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	The stimulative effects of endogenous opioids on endothelial cell proliferation, migration and angiogenesis in vitro
	Dai, X; Song, HJ; Cui, SG; Wang, T; Liu, Q; Wang, R; Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, 222 Tian Shui S Rd, Lanzhou 730000, Peoples R China.
刊名	EUROPEAN JOURNAL OF PHARMACOLOGY
	2010-02-25
卷号	628 期号:1-3 页码:42-50
关键词	Endomorphin-1 Endomorphin-2 Deltorphin I Angiogenesis HUVEC
ISSN号	0014-2999
DOI	10.1016/j.ejphar.2009.11.035
文献子类	Article
英文摘要	The opioid peptides modulate extensive bioactivities, including pain, cardiovascular response, development and further responses. In the present study, the stimulative effects of endogenous opioid peptides on angiogenesis are evaluated in the proliferation, migration, adhesion and tube formation assays of the human umbilical vein endothelial cell (HUVEC) for the first time. Endomorphin-1, endomorphin-2 and deltorphin I at physiological concentrations could stimulate HUVECs proliferation, migration, adhesion and tube formation in a dose dependent manner; whereas, they exhibited the cytotoxic effects on HUVECs at the higher doses in these assays. Naloxone, the nonselective opioid receptor antagonist, did not influence angiogenesis when it was administrated on its own; but it could antagonize the stimulative effects of the opioid peptides on angiogenesis when it was administrated in combination with the opioid peptides. Taken altogether, the results suggested that endogenous opioid peptides (endomorphin-1 and -2 and deltorphin 1) stimulated angiogenesis at the cellular level, and these effects were mediated by the opioid receptors. These data are significant for potential clinical implementation in future. (C) 2009 Elsevier B.V. All rights reserved.
学科主题	Pharmacology & Pharmacy
出版地	AMSTERDAM
资助项目	国家自然科学基金项目 ; 高等学校博士学科点专项科研基金
项目编号	National Natural Science Foundation of China [20525206, 20772052] ; Specialized Research Fund for the Doctoral Program in Higher Education Institutions ; Ministry of Education of China
语种	英语
WOS记录号	WOS:000274784500007
资助机构	NSFC ; MOE
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/121434]
专题	基础医学院_期刊论文
通讯作者	Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, 222 Tian Shui S Rd, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Dai, X,Song, HJ,Cui, SG,et al. The stimulative effects of endogenous opioids on endothelial cell proliferation, migration and angiogenesis in vitro[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2010,628(1-3):42-50.
APA	Dai, X.,Song, HJ.,Cui, SG.,Wang, T.,Liu, Q.,...&Wang, R .(2010).The stimulative effects of endogenous opioids on endothelial cell proliferation, migration and angiogenesis in vitro.EUROPEAN JOURNAL OF PHARMACOLOGY,628(1-3),42-50.
MLA	Dai, X,et al."The stimulative effects of endogenous opioids on endothelial cell proliferation, migration and angiogenesis in vitro".EUROPEAN JOURNAL OF PHARMACOLOGY 628.1-3(2010):42-50.