Design, Synthesis, Antifungal Activities and 3D-QSAR of New N,N '-Diacylhydrazines Containing 2,4-Dichlorophenoxy Moiety

doi:10.3390/ijms141121741

	Design, Synthesis, Antifungal Activities and 3D-QSAR of New N,N '-Diacylhydrazines Containing 2,4-Dichlorophenoxy Moiety
	Sun, Na-Bo 1; Shi, Yan-Xia 2; Liu, Xing-Hai 3; Ma, Yi 4; Tan, Cheng-Xia 3; Weng, Jian-Quan 3; Jin, Jian-Zhong 1; Li, Bao-Ju 2
刊名	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
	2013
卷号	14 期号:11 页码:21741-21756
关键词	N N-diacylhydrazines antifungal activity synthesis three-dimensional quantitative structure-activity relationships (3D-QSAR)
ISSN号	1422-0067
DOI	10.3390/ijms141121741
通讯作者	Sun, Na-Bo
英文摘要	A series of new N,N-diacylhydrazine derivatives were designed and synthesized. Their structures were verified by H-1-NMR, mass spectra (MS) and elemental analysis. The antifungal activities of these N,N-diacylhydrazines were evaluated. The bioassay results showed that most of these N,N-diacylhydrazines showed excellent antifungal activities against Cladosporium cucumerinum, Corynespora cassiicola, Sclerotinia sclerotiorum, Erysiphe cichoracearum, and Colletotrichum orbiculare in vivo. The half maximal effective concentration (EC50) of one of the compounds was also determined, and found to be comparable with a commercial drug. To further investigate the structure-activity relationship, comparative molecular field analysis (CoMFA) was performed on the basis of antifungal activity data. Both the steric and electronic field distributions of CoMFA are in good agreement in this study.
学科主题	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary ; CHEMISTRY, MULTIDISCIPLINARY
语种	英语
出版者	MDPI AG
WOS记录号	WOS:000328624400034
内容类型	期刊论文
源URL	[http://111.203.20.206/handle/2HMLN22E/101024]
专题	蔬菜花卉研究所_植物保护研究室
作者单位	1.Zhejiang Shuren Univ, Coll Biol & Environm Engn, Hangzhou 310015, Zhejiang, Peoples R China 2.Chinese Acad Agr Sci, Inst Vegetables & Flowers, Beijing 100081, Peoples R China 3.Zhejiang Univ Technol, Coll Chem Engn & Mat Sci, Hangzhou 310014, Zhejiang, Peoples R China 4.Nankai Univ, Natl Pesticidal Engn Ctr, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
推荐引用方式 GB/T 7714	Sun, Na-Bo,Shi, Yan-Xia,Liu, Xing-Hai,et al. Design, Synthesis, Antifungal Activities and 3D-QSAR of New N,N '-Diacylhydrazines Containing 2,4-Dichlorophenoxy Moiety[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2013,14(11):21741-21756.
APA	Sun, Na-Bo.,Shi, Yan-Xia.,Liu, Xing-Hai.,Ma, Yi.,Tan, Cheng-Xia.,...&Li, Bao-Ju.(2013).Design, Synthesis, Antifungal Activities and 3D-QSAR of New N,N '-Diacylhydrazines Containing 2,4-Dichlorophenoxy Moiety.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,14(11),21741-21756.
MLA	Sun, Na-Bo,et al."Design, Synthesis, Antifungal Activities and 3D-QSAR of New N,N '-Diacylhydrazines Containing 2,4-Dichlorophenoxy Moiety".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 14.11(2013):21741-21756.