Synthesis and Evaluation of Novel N-(4 '-Arylpyrimidin-2 '-yl) Sulfonylurea Derivatives as Potential Antifungal Agents

doi:10.1007/s40242-015-4362-5

	Synthesis and Evaluation of Novel N-(4 '-Arylpyrimidin-2 '-yl) Sulfonylurea Derivatives as Potential Antifungal Agents
	Chen Wei 1,2; Li Yuxin 1,2; Shi Yanxia 3; Wei Wei 1,2; Chen Youwei 1,2; Li Yonghong 1; Liu Jingbo 1,2; Li Baoju 3; Li Zhengming 1,2
刊名	CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
	2015
卷号	31 期号:2 页码:218-223
关键词	Acetohydroxyacid synthase Sulfonylurea Fungicidal activity Substituted pyrimidine
ISSN号	1005-9040
DOI	10.1007/s40242-015-4362-5
通讯作者	Chen Wei
英文摘要	Sulfonylureas(SUs) are potent and selective inhibitors of acetohydroxyacid synthase and has been used as herbicides. Some SUs also displayed other biological activities. In order to discuss the antifungal activity of SUs, a series of novel SUs containing aryl-substituted pyrimidine moieties was designed and synthesized. The preliminary bioassay showed that the title compounds exhibited moderate to favorable fungicidal activities in vivo. Especially, compound 9b exhibited more efficacy than the controls against five fungi at 25 mg/L. These promising results indicate that an aryl group on pyrimidine ring is favorable for antifungal activity and SUs are potential inhibitors for some phytopathogenic fungi.
学科主题	Chemistry, Multidisciplinary
语种	英语
出版者	HIGHER EDUCATION PRESS
WOS记录号	WOS:000354441500011
内容类型	期刊论文
源URL	[http://111.203.20.206/handle/2HMLN22E/100907]
专题	蔬菜花卉研究所_植物保护研究室
作者单位	1.Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China 2.Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China 3.Chinese Acad Agr Sci, Inst Vegetables & Flowers, Beijing 100081, Peoples R China
推荐引用方式 GB/T 7714	Chen Wei,Li Yuxin,Shi Yanxia,et al. Synthesis and Evaluation of Novel N-(4 '-Arylpyrimidin-2 '-yl) Sulfonylurea Derivatives as Potential Antifungal Agents[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2015,31(2):218-223.
APA	Chen Wei.,Li Yuxin.,Shi Yanxia.,Wei Wei.,Chen Youwei.,...&Li Zhengming.(2015).Synthesis and Evaluation of Novel N-(4 '-Arylpyrimidin-2 '-yl) Sulfonylurea Derivatives as Potential Antifungal Agents.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,31(2),218-223.
MLA	Chen Wei,et al."Synthesis and Evaluation of Novel N-(4 '-Arylpyrimidin-2 '-yl) Sulfonylurea Derivatives as Potential Antifungal Agents".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 31.2(2015):218-223.