Syntheses, biological activities and SAR studies of novel carboxamide compounds containing piperazine and arylsulfonyl moieties

doi:10.1016/j.ejmech.2016.04.005

	Syntheses, biological activities and SAR studies of novel carboxamide compounds containing piperazine and arylsulfonyl moieties
	Wang, Bao-Lei 1; Shi, Yan-Xia 2; Zhang, Shu-Jun 1; Ma, Yi 1; Wang, Hong-Xue 1; Zhang, Li-Yuan 1; Wei, Wei 1; Liu, Xing-Hai 1; Li, Yong-Hong 1; Li, Zheng-Ming 1
刊名	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
	2016
卷号	117 页码:167-178
关键词	Piperazine derivatives Arylsulfonyl group Biological activities 3D-QSAR Theoretical calculation
ISSN号	0223-5234
DOI	10.1016/j.ejmech.2016.04.005
通讯作者	Wang, Bao-Lei
英文摘要	A series of novel carboxamide compounds 19a-19j, 20a-20j and 22a-22d containing piperazine and arylsulfonyl moieties have been synthesized. The bioassay results showed that some compounds exhibited favorable herbicidal activities against dicotyledonous plants and many of them possessed excellent antifungal activities. Among 24 novel compounds, some showed superiority over the commercial fungicides Chlorothalonil, Dimethomorph, Thiophanate-methyl, Iprodione, and Zhongshengmycin at 500 mg/L concentration. Some compounds also exhibited high KARI inhibitory activity at 100 mu g/mL concentration and could be used as new KARI lead inhibitors for further studies. Moreover, SAR of these new compounds were comprehensively investigated using different computational methods in which 3D-QSAR model obtained provided useful information for further structural optimization for the discovery of new fungicides. The results of this research will contribute to explore comprehensive biological activities of piperazine-containing compounds in different areas of chemistry. (C) 2016 Elsevier Masson SAS. All rights reserved.
学科主题	Chemistry, Medicinal
语种	英语
出版者	ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
WOS记录号	WOS:000376837800014
内容类型	期刊论文
源URL	[http://111.203.20.206/handle/2HMLN22E/100809]
专题	蔬菜花卉研究所_植物保护研究室
作者单位	1.Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn, Natl Pesticide Engn Res Ctr Tianjin, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China 2.Chinese Acad Agr Sci, Inst Vegetables & Flowers, Beijing 100081, Peoples R China
推荐引用方式 GB/T 7714	Wang, Bao-Lei,Shi, Yan-Xia,Zhang, Shu-Jun,et al. Syntheses, biological activities and SAR studies of novel carboxamide compounds containing piperazine and arylsulfonyl moieties[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2016,117:167-178.
APA	Wang, Bao-Lei.,Shi, Yan-Xia.,Zhang, Shu-Jun.,Ma, Yi.,Wang, Hong-Xue.,...&Li, Bao-Ju.(2016).Syntheses, biological activities and SAR studies of novel carboxamide compounds containing piperazine and arylsulfonyl moieties.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,117,167-178.
MLA	Wang, Bao-Lei,et al."Syntheses, biological activities and SAR studies of novel carboxamide compounds containing piperazine and arylsulfonyl moieties".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 117(2016):167-178.