Escape from preferential retention following repeated whole genome duplications in plants

doi:10.3389/fpls.2012.00094

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	Escape from preferential retention following repeated whole genome duplications in plants
	Schnable, James C.1; Wang, Xiaowu 2; Pires, J. Chris 3; Freeling, Michael 1
刊名	FRONTIERS IN PLANT SCIENCE
	2012
卷号	3 页码:-
关键词	polyploidy gene dosage gene loss genome evolution comparative genomics crucifers grasses
ISSN号	1664-462X
DOI	10.3389/fpls.2012.00094
通讯作者	Schnable, James C.
英文摘要	The well supported gene dosage hypothesis predicts that genes encoding proteins engaged in dose sensitive interactions cannot be reduced back to single copies once all interacting partners are simultaneously duplicated in a whole genome duplication. The genomes of extant flowering plants are the result of many sequential rounds of whole genome duplication, yet the fraction of genomes devoted to encoding complex molecular machines does not increase as fast as expected through multiple rounds of whole genome duplications. Using parallel interspecies genomic comparisons in the grasses and crucifers, we demonstrate that genes retained as duplicates following a whole genome duplication have only a 50% chance of being retained as duplicates in a second whole genome duplication. Genes which fractionated to a single copy following a second whole genome duplication tend to be the member of a gene pair with less complex promoters, lower levels of expression, and to be under lower levels of purifying selection. We suggest the copy with lower levels of expression and less purifying selection contributes less to effective gene-product dosage and therefore is under less dosage constraint in future whole genome duplications, providing an explanation for why flowering plant genomes are not overrun with subunits of large dose sensitive protein complexes.
学科主题	Plant Sciences
语种	英语
出版者	FRONTIERS RESEARCH FOUNDATION
WOS记录号	WOS:000208837900095
内容类型	期刊论文
源URL	[http://111.203.20.206/handle/2HMLN22E/101126]
专题	蔬菜花卉研究所_职能部门
作者单位	1.Univ Calif Berkeley, Freeling Lab, Berkeley, CA 94720 USA 2.Chinese Acad Agr Sci, Inst Vegetables & Flowers, Dept Biotechnol, Mol Genet Lab, Beijing 100193, Peoples R China 3.Univ Missouri, Bond Life Sci Ctr, Columbia, MO USA
推荐引用方式 GB/T 7714	Schnable, James C.,Wang, Xiaowu,Pires, J. Chris,et al. Escape from preferential retention following repeated whole genome duplications in plants[J]. FRONTIERS IN PLANT SCIENCE,2012,3:-.
APA	Schnable, James C.,Wang, Xiaowu,Pires, J. Chris,&Freeling, Michael.(2012).Escape from preferential retention following repeated whole genome duplications in plants.FRONTIERS IN PLANT SCIENCE,3,-.
MLA	Schnable, James C.,et al."Escape from preferential retention following repeated whole genome duplications in plants".FRONTIERS IN PLANT SCIENCE 3(2012):-.