HLA-DRB1 Shared Epitope-Dependent DR-DQ Haplotypes Are Associated with Both Anti-CCP-Positive and -Negative Rheumatoid Arthritis in Chinese Han

doi:10.1371/journal.pone.0071373

CORC > 中国农业科学院 > 蔬菜花卉研究所

	HLA-DRB1 Shared Epitope-Dependent DR-DQ Haplotypes Are Associated with Both Anti-CCP-Positive and -Negative Rheumatoid Arthritis in Chinese Han
	Liu, Xu 1; Guo, Jianping 1; Jia, Yuan 1; Zhao, Yi 2; Liu, Xia 3; Cheng, Feng 4; Li, Xiaoxia 2; Zheng, Yi 5; Shi, Xuhua 5; Li, Haiyun 5
刊名	PLOS ONE
	2013
卷号	8 期号:8 页码:-
ISSN号	1932-6203
DOI	10.1371/journal.pone.0071373
通讯作者	Liu, Xu
英文摘要	The association between Human Leukocyte Antigen (HLA) class II and rheumatoid arthritis (RA) has been extensively studied, but few reported DR-DQ haplotype. Here we investigated the association of HLA-DRB1, DQA1, DQB1, and DR-DQ haplotypes with RA susceptibility and with anti-CCP antibodies in 281 RA patients and 297 control in Han population. High-resolution genotyping were performed. The HLA-DRB1 shared epitope (SE)-encoding allele *0405 displayed the most significant RA association (P = 1.35x10(-6)). The grouped DRB1 SE alleles showed great association with RA (P = 3.88x10(-13)). The DRB1 DRRAA alleles displayed significant protective effects (P = 0.021). The SE-dependent DR-DQ haplotype SE-DQ3/4/5 remained strong association with both anti-CCP -positive (P = 3.71x10(-13)) and -negative RA (P = 3.89x10(-5)). Our study revealed that SE alleles and its haplotypes SE-DQ3/4/5 were highly associated with RA susceptibility in Han population. The SE-DQ3/4/5 haplotypes were associated with both anti-CCP positive RA and -negative RA.
学科主题	Multidisciplinary Sciences ; MULTIDISCIPLINARY SCIENCES
语种	英语
出版者	PUBLIC LIBRARY SCIENCE
WOS记录号	WOS:000323097300111
内容类型	期刊论文
源URL	[http://111.203.20.206/handle/2HMLN22E/101882]
专题	蔬菜花卉研究所
作者单位	1.Peking Univ, Dept Rheumatol & Immunol, Peoples Hosp, Beijing 100871, Peoples R China 2.Xuanwu Hosp Capital Med Univ, Dept Rheumatol, Beijing, Peoples R China 3.China Japan Friendship Hosp, Dept Rheumatol, Beijing, Peoples R China 4.Chinese Acad Agr Sci, Inst Vegetables & Flowers, Beijing 100193, Peoples R China 5.Chao Yang Hosp, Dept Rheumatol, Beijing, Peoples R China 6.Beijing Hosp, Dept Rheumatol, Minist Hlth, Beijing, Peoples R China 7.Beijing Jishuitan Hosp, Dept Rheumatol, Beijing, Peoples R China 8.Capital Med Univ, Beijing Anzhen Hosp, Dept Internal Med, Beijing, Peoples R China 9.Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden
推荐引用方式 GB/T 7714	Liu, Xu,Guo, Jianping,Jia, Yuan,et al. HLA-DRB1 Shared Epitope-Dependent DR-DQ Haplotypes Are Associated with Both Anti-CCP-Positive and -Negative Rheumatoid Arthritis in Chinese Han[J]. PLOS ONE,2013,8(8):-.
APA	Liu, Xu.,Guo, Jianping.,Jia, Yuan.,Zhao, Yi.,Liu, Xia.,...&Li, ZhangGuo.(2013).HLA-DRB1 Shared Epitope-Dependent DR-DQ Haplotypes Are Associated with Both Anti-CCP-Positive and -Negative Rheumatoid Arthritis in Chinese Han.PLOS ONE,8(8),-.
MLA	Liu, Xu,et al."HLA-DRB1 Shared Epitope-Dependent DR-DQ Haplotypes Are Associated with Both Anti-CCP-Positive and -Negative Rheumatoid Arthritis in Chinese Han".PLOS ONE 8.8(2013):-.