Combined Molecular Modeling Studies of Hsp90 Chaperone Inhibitors by Pharmacophore Model;Molecular Docking and 3D-QSAR

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	Combined Molecular Modeling Studies of Hsp90 Chaperone Inhibitors by Pharmacophore Model;Molecular Docking and 3D-QSAR
	Yang Y(杨颖); Liu HX(刘焕香); Du J(杜娟); Qin J(秦晋); Yao XJ(姚小军)
	2009-12-01
会议名称	甘肃省化学会二十六届年会暨第八届中学化学教学经验交流会
关键词	QSAR scaffold interacting pyrazole residues CoMFA Inhibition hypothesis alignment bioactive
页码	1
中文摘要	Inhibition of the protein chaperone Hsp90 is a promising approach to cancer therapy.A combined molecular modeling study include pharmacophore modeling,molecular docking and 3D-QSAR were performed to investigate a series of pyrazole-/isoxazole-scaffold inhibitors of human Hsp90α.The best pharmacop...
会议录	甘肃省化学会二十六届年会暨第八届中学化学教学经验交流会论文集
语种	中文
内容类型	会议论文
源URL	[http://202.201.7.4/handle/262010/108755]
专题	化学化工学院_会议论文
推荐引用方式 GB/T 7714	Yang Y,Liu HX,Du J,et al. Combined Molecular Modeling Studies of Hsp90 Chaperone Inhibitors by Pharmacophore Model;Molecular Docking and 3D-QSAR[C]. 见:甘肃省化学会二十六届年会暨第八届中学化学教学经验交流会.