Ultrafiltration LC-ESI-MSn screening of MMP-2 inhibitors from selected Chinese medicinal herbs Smilax glabra Roxb., Smilax china L. and Saposhnikovia divaricata (Turcz.) Schischk as potential functional food ingredients

doi:10.1016/j.jff.2015.03.038

CORC > 中国农业科学院 > 植物保护研究所

	Ultrafiltration LC-ESI-MSn screening of MMP-2 inhibitors from selected Chinese medicinal herbs Smilax glabra Roxb., Smilax china L. and Saposhnikovia divaricata (Turcz.) Schischk as potential functional food ingredients
	Li, Li 1; Li, Bo 1; Zhang, Huirong 2; Zhao, Anqi 1; Han, Binhua 1; Liu, Chunming 1; Tsao, Rong 3
刊名	JOURNAL OF FUNCTIONAL FOODS
	2015
卷号	15 页码:389-395
关键词	S. glabra S. china S. divaricata MMP-2 inhibitor Ultrafiltration LC-ESI-MSn
ISSN号	1756-4646
DOI	10.1016/j.jff.2015.03.038
通讯作者	Li, Li
英文摘要	In vitro Matrix metalloproteases-2 (MMP-2) inhibition assay and ultrafiltration liquid chromatography coupled to electrospray ionization tandem mass spectrometry (ultrafiltration LC-ESI-MSn) were combined to screen MMP-2 inhibitors from three Chinese medicinal herbs, Smilax glabra Roxb., Smilax china L. and Saposhnikovia divaricata (Turcz.) Schischk as potential functional food ingredients. Results showed that extracts of two Smilax species and the three major components resveratrol, engelitin and asibinn, and extract of S. divaricata and its major component 4'-O-beta-D-glucosy1-5-O-methylvisamminol and three other chromones were strong MMP-2 inhibitors. Resveratrol and 4'-O-beta-D-glucosy1-5-O-methylvisamminol had the highest binding affinity to MMP-2 and were the main contributors to the MMP-2 activity of Smilax and Saposhnikovia extracts, respectively. The present results further suggest that ultrafiltration LC-ESI-MS' is a valid, selective and effective method, and can be used to screen MMP-2 inhibitors from other plants such as grapes that contain resveratrol as functional foods and nutraceuticals. Crown Copyright (C) 2015 Published by Elsevier Ltd. All rights reserved.
学科主题	Food Science & Technology
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000355240800037
内容类型	期刊论文
源URL	[http://111.203.20.206/handle/2HMLN22E/11726]
专题	植物保护研究所
作者单位	1.Changchun Normal Univ, Coll Chem, Changchun 130032, Peoples R China 2.Chinese Acad Agr Sci, Inst Plant Protect, Beijing 100193, Peoples R China 3.Agr & Agri Food Canada, Guelph Food Res Ctr, Guelph, ON N1G 5C9, Canada
推荐引用方式 GB/T 7714	Li, Li,Li, Bo,Zhang, Huirong,et al. Ultrafiltration LC-ESI-MSn screening of MMP-2 inhibitors from selected Chinese medicinal herbs Smilax glabra Roxb., Smilax china L. and Saposhnikovia divaricata (Turcz.) Schischk as potential functional food ingredients[J]. JOURNAL OF FUNCTIONAL FOODS,2015,15:389-395.
APA	Li, Li.,Li, Bo.,Zhang, Huirong.,Zhao, Anqi.,Han, Binhua.,...&Tsao, Rong.(2015).Ultrafiltration LC-ESI-MSn screening of MMP-2 inhibitors from selected Chinese medicinal herbs Smilax glabra Roxb., Smilax china L. and Saposhnikovia divaricata (Turcz.) Schischk as potential functional food ingredients.JOURNAL OF FUNCTIONAL FOODS,15,389-395.
MLA	Li, Li,et al."Ultrafiltration LC-ESI-MSn screening of MMP-2 inhibitors from selected Chinese medicinal herbs Smilax glabra Roxb., Smilax china L. and Saposhnikovia divaricata (Turcz.) Schischk as potential functional food ingredients".JOURNAL OF FUNCTIONAL FOODS 15(2015):389-395.