Synthesis and characterization of photo-cross-linked hydrogels based on biodegradable polyphosphoesters and poly(ethylene glycol) copolymers

	Synthesis and characterization of photo-cross-linked hydrogels based on biodegradable polyphosphoesters and poly(ethylene glycol) copolymers
	Du JZ ; Sun TM ; Weng SQ ; Chen XS ; Wang J
刊名	biomacromolecules
	2007
卷号	8 期号:11 页码:3375-3381
关键词	RING-OPENING POLYMERIZATION IN-VITRO BLOCK-COPOLYMERS DELIVERY SYSTEMS DRUG-DELIVERY NETWORKS BIONANOTECHNOLOGY CYTOCOMPATIBILITY POLYESTER MEDICINE
ISSN号	1525-7797
通讯作者	wang j
中文摘要	novel biodegradable hydrogels by photo-cross-linking macromers based on polyphosphoesters and poly(ethylene glycol) (peg) are reported. photo-cross-linkable macromers were synthesized by ring-opening polymerization of the cyclic phosphoester monomer 2-(2-oxo-1,3,2-dioxaphospholoyloxy) ethyl methacrylate (opema) using peg as the initiator and stannous octoate as the catalyst. the macrorners were characterized by h-1 nmr, fourier transform infrared spectroscopy, and gel permeation chromatography measurements. the content of polyphosphoester in the macromer was controlled by varying the feed ratio of opema to peg. hydrogels were fabricated by exposing aqueous solutions of macromers with 0.05% (w/w) photoinitiator to uv light irradiation, and their swelling kinetics as well as degradation behaviors were evaluated. the results demonstrated that cross-linking density and ph values strongly affected the degradation rates. the macromers was compatible to osteoblast cells, not exhibiting significant cytotoxicity up to 0.5 mg/ml. "live/dead" cell staining assay also demonstrated that a large majority of the osteoblast cells remained viable after encapsulation into the hydrogel constructs, showing their potential as tissue engineering scaffolds.
收录类别	SCI
语种	英语
WOS记录号	WOS:000250960300013
公开日期	2010-07-13
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/14689]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Du JZ,Sun TM,Weng SQ,et al. Synthesis and characterization of photo-cross-linked hydrogels based on biodegradable polyphosphoesters and poly(ethylene glycol) copolymers[J]. biomacromolecules,2007,8(11):3375-3381.
APA	Du JZ,Sun TM,Weng SQ,Chen XS,&Wang J.(2007).Synthesis and characterization of photo-cross-linked hydrogels based on biodegradable polyphosphoesters and poly(ethylene glycol) copolymers.biomacromolecules,8(11),3375-3381.
MLA	Du JZ,et al."Synthesis and characterization of photo-cross-linked hydrogels based on biodegradable polyphosphoesters and poly(ethylene glycol) copolymers".biomacromolecules 8.11(2007):3375-3381.