Dynamics and intrinsic statistical fluctuations of a gene switch

	Dynamics and intrinsic statistical fluctuations of a gene switch
	Lepzelter D ; Kim KY ; Wang J
刊名	journal of physical chemistry b
	2007
卷号	111 期号:34 页码:10239-10247
关键词	ESCHERICHIA-COLI FIELD-THEORY EXPRESSION NETWORK NOISE CELLS ULTRASENSITIVITY STOCHASTICITY STABILITY MOLECULE
ISSN号	1520-6106
通讯作者	wang j
中文摘要	we studied a simple gene regulatory network, the toggle switch. specifically, we examined the means and statistical fluctuations in numbers of proteins. we found that when omega, the ratio of rates of protein-gene unbinding to protein degradation, was between similar to 10(-3) and similar to 10, the fluctuations were much larger than those we would have expected from poisson statistics. in addition, we examined characteristic time values for system relaxation and found both that they increased with omega and that they have significant phase transition effects, with a secondary time scale appearing near the boundary between bistable and other phases. last, we discuss the bistability of the toggle switch.
收录类别	SCI
语种	英语
WOS记录号	WOS:000248929900026
公开日期	2010-07-13
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/14063]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Lepzelter D,Kim KY,Wang J. Dynamics and intrinsic statistical fluctuations of a gene switch[J]. journal of physical chemistry b,2007,111(34):10239-10247.
APA	Lepzelter D,Kim KY,&Wang J.(2007).Dynamics and intrinsic statistical fluctuations of a gene switch.journal of physical chemistry b,111(34),10239-10247.
MLA	Lepzelter D,et al."Dynamics and intrinsic statistical fluctuations of a gene switch".journal of physical chemistry b 111.34(2007):10239-10247.