Special enhanced synergetic effect of MoS₂ quantum dots (MoS₂ QDs) and graphene on metal-organic frameworks for photocatalytic hydrogen evolution is obtained here. The photocatalytic activity of H₂ evolution reach 186.37 mu mol over the EY-sensitized 5 rift% MoS₂ QDs/UiO-66-NH₂/G irradiated under visible light irradiation (λ ≥ 420nm) in the first 3 h, and the apparent quantum efficiency (AQE) is 40.5% at 430 nm. The synergistic effect between MoS₂ QDs and graphene together with UiO-66-NH₂ is corroborated by photo-luminescence spectra, electro-chemical and photo-electro-chemical experiments. It demonstrate that the charge separation and the electrons transfer are more efficient with the aid of the MoS₂ QDs and graphene. MoS₂ QDs might be a potential photocatalyst for design new type of catalysts in photocatalysis proton reduction.