Genetic Adaptation of Schizothoracine Fish to the Phased Uplifting of the Qinghai-Tibetan Plateau

CORC > 水生生物研究所 > 中科院水生所知识产出（2009年前） > 水生生物分子与细胞生物学研究中心 > 期刊论文

	Genetic Adaptation of Schizothoracine Fish to the Phased Uplifting of the Qinghai-Tibetan Plateau
	Zhang, Dongsheng 1; Yu, Mengchao 1; Hu, Peng 1; Peng, Sihua 1; Liu, Yimeng 1; Li, Weiwen 2; Wang, Congcong 2; He, Shunping 3; Zhai, Wanying 1; Xu, Qianghua 2
刊名	G3-GENES GENOMES GENETICS
	2017-04-01
卷号	7 期号:4 页码:1267-1276
关键词	Qinghai-Tibetan Plateau adaptive evolution hypoxia Schizothoracine fish GenPred Shared Data Resources Genomic Selection
ISSN号	2160-1836
英文摘要	Many species of Schizothoracine, a subfamily of Cyprinidae, are highly endemic to the Qinghai-Tibetan Plateau (QTP). To characterize the adaptive changes associated with the Schizothoracine expansion at high altitudes, we sequenced tissue transcriptomes of two highland and two subhighland Schizothoracines and analyzed gene evolution patterns by comparing with lowland cyprinids. Phylogenetic tree reconstruction and divergence time estimation indicated that the common ancestor of Schizothoracine fish lived approximate to 32.7 million years ago (MYA), coinciding with the timing of the first phase of QTP uplifting. Both high- and subhigh-Schizothoracines demonstrated elevated dN/dS ratios in the protein-coding genes compared to lowland cyprinids, from which some biological processes implicated in altitude adaptation were commonly identified. On the other hand, the highland and subhighland lineages presented drastically divergent landscapes of positively selected genes (PSGs), enriched with very different gene ontology (GO) profiles, including those in sensory organ morphogenesis, regulation of protein ubiquitination, blood circulation, and blood vessel development. These results indicated different selection pressures imposed on the highland and subhighland lineages of the Schizothoracine subfamily, with a higher number of genes in the high-altitude species involved in adaptations such as sensory perception, blood circulation, and protein metabolism. Our study indicated divergent genetic adaptations in the aquatic species facing the phased uplifting of QTP.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Genetics & Heredity
研究领域[WOS]	Genetics & Heredity
关键词[WOS]	HIGH-ALTITUDE ADAPTATION ; COMPREHENSIVE TRANSCRIPTOME ANALYSIS ; REVEALS ADAPTATION ; ADAPTIVE EVOLUTION ; PHYLOGENETIC ANALYSIS ; MOLECULAR PHYLOGENY ; GENOME SEQUENCE ; DRAFT GENOME ; DNA-REPAIR ; CYPRINIDAE
收录类别	SCI
语种	英语
WOS记录号	WOS:000398840700020
内容类型	期刊论文
源URL	[http://ir.ihb.ac.cn/handle/342005/29180]
专题	水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文
作者单位	1.Shanghai Ocean Univ, Coll Fisheries & Life Sci, Key Lab Aquaculture Resources & Utilizat, Minist Educ, 999 Huchenghuan Rd, Shanghai 201306, Peoples R China 2.Shanghai Ocean Univ, Coll Marine Sci, Key Lab Sustainable Exploitat Ocean Fisheries Res, Minist Educ, 999 Huchenghuan Rd, Shanghai 201306, Peoples R China 3.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China 4.Qingdao Natl Lab Marine Sci & Technol, Marine Biol & Biotechnol Lab, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Dongsheng,Yu, Mengchao,Hu, Peng,et al. Genetic Adaptation of Schizothoracine Fish to the Phased Uplifting of the Qinghai-Tibetan Plateau[J]. G3-GENES GENOMES GENETICS,2017,7(4):1267-1276.
APA	Zhang, Dongsheng.,Yu, Mengchao.,Hu, Peng.,Peng, Sihua.,Liu, Yimeng.,...&Chen, Liangbiao.(2017).Genetic Adaptation of Schizothoracine Fish to the Phased Uplifting of the Qinghai-Tibetan Plateau.G3-GENES GENOMES GENETICS,7(4),1267-1276.
MLA	Zhang, Dongsheng,et al."Genetic Adaptation of Schizothoracine Fish to the Phased Uplifting of the Qinghai-Tibetan Plateau".G3-GENES GENOMES GENETICS 7.4(2017):1267-1276.