Titanium-Mediated Direct Carbon-Carbon Double Bond Formation to alpha-Trifluoromethyl Acids: A New Contribution to the Knoevenagel Reaction and a High-Yielding and Stereoselective Synthesis of alpha-Trifluoromethylacrylic Acids

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	Titanium-Mediated Direct Carbon-Carbon Double Bond Formation to alpha-Trifluoromethyl Acids: A New Contribution to the Knoevenagel Reaction and a High-Yielding and Stereoselective Synthesis of alpha-Trifluoromethylacrylic Acids
	Liu YM(刘艳妹) ; Lai H(赖华) ; Rong B(容波) ; Zhou T(周铁) ; Hong J(洪家) ; Yuan C(袁超) ; Zhao SJ(赵淑静) ; Zhao XL(赵小龙) ; Jiang B(姜标) ; Fang Q(房强)
刊名	Adv. Synth. Catal.
	2011
卷号	353 期号:17 页码:3161-3165
ISSN号	1615-4150
其他题名	钛参与下直接生成含不饱和双键的α-三氟甲基酸类化合物: Knoevenagel反应的新应用以及高效立体选择性合成α-三氟甲基丙烯酸类化合物新方法
通讯作者	房强
英文摘要	An efficient strategy for a high-yielding and stereoselective synthesis of a-trifluoromethyl unsaturated carboxylic acids directly from the reactions of 3,3,3-trifluoropropanoic acid (CF(3)CH(2)COOH) with various aryl aldehydes in the presence of titanium tetrachloride (TiCl(4)) is reported here for the first time, which is a valuable expansion for the classical Knoevenagel reaction. Because these compounds may have potential applications in organic electronics and can be easily converted to the corresponding fluorinated alcohols and amino acids with excellent bioactivity, this route should be a good choice for the preparation of alpha-trifluoromethyl-containing derivatives.
学科主题	金属有机化学 ; 氟化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1002/adsc.201100339
语种	英语
WOS记录号	WOS:000298171500015
公开日期	2013-02-25
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/20289]
专题	上海有机化学研究所_中科院天然产物有机化学重点实验室
推荐引用方式 GB/T 7714	Liu YM,Lai H,Rong B,et al. Titanium-Mediated Direct Carbon-Carbon Double Bond Formation to alpha-Trifluoromethyl Acids: A New Contribution to the Knoevenagel Reaction and a High-Yielding and Stereoselective Synthesis of alpha-Trifluoromethylacrylic Acids[J]. Adv. Synth. Catal.,2011,353(17):3161-3165.
APA	刘艳妹.,赖华.,容波.,周铁.,洪家.,...&房强.(2011).Titanium-Mediated Direct Carbon-Carbon Double Bond Formation to alpha-Trifluoromethyl Acids: A New Contribution to the Knoevenagel Reaction and a High-Yielding and Stereoselective Synthesis of alpha-Trifluoromethylacrylic Acids.Adv. Synth. Catal.,353(17),3161-3165.
MLA	刘艳妹,et al."Titanium-Mediated Direct Carbon-Carbon Double Bond Formation to alpha-Trifluoromethyl Acids: A New Contribution to the Knoevenagel Reaction and a High-Yielding and Stereoselective Synthesis of alpha-Trifluoromethylacrylic Acids".Adv. Synth. Catal. 353.17(2011):3161-3165.