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题名下调Annexin A3 表达对肺腺癌生物学行为的影响及分子机制探讨; Study on the effects of down-regulating Annexin A3 expression on biological behaviors of lung adenocarcinoma and its molecular mechanism
作者刘青青
答辩日期2017-03-23 ; 2015-05-18
导师刘迎福
关键词肺腺癌 转移 Annexin A3 Lung adenocarcinoma Metastasis Annexin A3
英文摘要肺癌是我国第一大癌症,其发病率和死亡率均居恶性肿瘤之首,严重危害人类健康。肺癌按组织学类型可分为鳞癌、腺癌、小细胞癌和大细胞癌。近年来,肺腺癌(lungadenocarcinoma,AdC)的发病率呈逐步上升趋势,且患者死亡率高、预后极差。癌细胞易转移是肺腺癌患者预后差的主要原因,因此,探寻肺腺癌转移的分子机制及其新的治疗靶标,对于提高肺腺癌患者预后意义重大。我们前期研究中,采用定量蛋白质组学技术鉴定出AnnexinA3(Anxa3)为一个新的肺腺癌转移相关分子,并在大量的肺腺癌临床样本中分析发现Anxa3表达与肺腺癌转移及预后密切相关,Anxa3高表达是肺腺癌淋巴结转移的危险因子及独立的预后...; Lung cancer is the most common cancer in our country, which has the highest incidence and mortality rates among all kinds of cancer, and has caused serious harm to human health. The histological types of lung cancer include squamous cell carcinoma, adenocarcinoma, small cell carcinoma and large cell carcinoma. In recent years, the incidence of lung adenocarcinoma has been gradually rising, with hi...; 学位:理学硕士; 院系专业:医学院_微生物学; 学号:24520121153205
语种zh_CN
出处http://210.34.4.13:8080/lunwen/detail.asp?serial=51510
内容类型学位论文
源URL[http://dspace.xmu.edu.cn/handle/2288/135127]  
专题医学院-学位论文
推荐引用方式
GB/T 7714
刘青青. 下调Annexin A3 表达对肺腺癌生物学行为的影响及分子机制探讨, Study on the effects of down-regulating Annexin A3 expression on biological behaviors of lung adenocarcinoma and its molecular mechanism[D]. 2017, 2015.
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