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	同一患者中甲状腺良性瘤与癌组织DNA甲基化差异基因的炎症相关信号通路分析; Inflammation-related signaling pathways of differently-methylated DNA from benign and malignant thyroid tumors in one patient
	顾龙 ; 蔡良良 ; 刘国彦 ; 阮润生 ; 曾骥孟
	2015-03-25
关键词	甲状腺肿瘤 甲状腺乳头状癌 甲状腺良性瘤 DNA甲基化 信号通路 炎症 Thyroid neoplasms Papillary thyroid carcinoma Thyroid benign tumor DNA methylation Signaling pathway Inflammation
英文摘要	目的:研究同一患者体内甲状腺良性瘤与癌组织在dnA甲基化方面的差异,从而揭示dnA甲基化在肿瘤发生发展中的重要作用。方法:使用基因甲基化芯片技术对同一患者的并发甲状腺癌、甲状腺良性瘤组织样本的基因组甲基化水平进行检测,对筛选出的差异化显著的基因进行生物信息学分析得到功能基因的信号通路,并针对与甲状腺癌明显相关的信号通路进行分析讨论。结果:甲状腺的良性瘤与癌在dnA甲基化水平上存在显著差异;参与恶性肿瘤相关的信号通路包括T细胞受体的信号通路,JAk-STAT信号通路与细胞因子-细胞因子受体相互作用信号通路等炎症相关信号通路。结论:研究得出炎症的相关生物信息学通路与甲状腺肿瘤的发生发展密切相关,为甲状腺恶性肿瘤的发生发展机制的阐明与潜在药物靶点的选择提供新的思路与方向。; Objective To determine the possible differences in DNA methylation of benign and malignant thyroid tumors and its role in tumorgenesis and tumor progression.Methods Infinium human methylation 450 bead chip platform was utilized to screen the whole-genome of benign and malignant thyroid tumor tissues surgically removed from a patient for the determination of their DNA methylation levels.The genes with significant differences in methylation were analyzed for their functional pathways with bioinformatics.Results There were significant differences in DNA methylation between benign and malignant thyroid tumor.The inflammation-related pathways, such as T cell, Jak-STAT and cytokine-cytokine receptor signaling pathways involved in the biological process of tumorgenesis and tumor progression.Conclusions The differences in DNA methylation between benign and malignant reveal a close relationship between inflammation and tumorgenesis and tumor progression and provide a novel method for investigation of thyroid cancer development and target drug discovery.; 国家自然科学基金(编号:81272445); 厦门市科技局国家对台科技合作项目(编号:350Z20121153)
语种	zh_CN
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/123598]
专题	药学院－已发表论文
推荐引用方式 GB/T 7714	顾龙,蔡良良,刘国彦,等. 同一患者中甲状腺良性瘤与癌组织DNA甲基化差异基因的炎症相关信号通路分析, Inflammation-related signaling pathways of differently-methylated DNA from benign and malignant thyroid tumors in one patient[J],2015.
APA	顾龙,蔡良良,刘国彦,阮润生,&曾骥孟.(2015).同一患者中甲状腺良性瘤与癌组织DNA甲基化差异基因的炎症相关信号通路分析..
MLA	顾龙,et al."同一患者中甲状腺良性瘤与癌组织DNA甲基化差异基因的炎症相关信号通路分析".(2015).

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