| FGFR2基因rs2981582位点单核苷酸多态性与乳腺癌易感性的关系; Relationship between polymorphism of fibroblast growth factor receptor 2 rs2981582 and susceptibility of breast cancer | |
| 付莉 ; 陈双龙 ; 黄红浪 ; 骆伟珍 ; 范钦 | |
| 2013-04-19 | |
| 关键词 | 乳腺肿瘤 乳腺癌 酪氨酸激酶受体基因 成纤维细胞生长因子受体2 单核苷酸多态性 雌激素受体 breast neoplasms breast cancer tyrosine kinase receptor gene fibroblast growth factor receptor 2 single nucleotide polymorphism estrogen receptor |
| 英文摘要 | 目的探讨成纤维细胞生长因子受体2(fgfr2)基因rS2981582位点单核苷酸多态性(SnP)与乳腺癌易感性之间的关系。方法对193例乳腺癌患者和150例正常女性进行病例对照研究,采用dnA直接测序法同时检测其fgfr2基因第二内含子的SnP位点rS2981582的基因及基因型。结果乳腺癌患者fgfr2基因rS2981582位点的基因分布频率与正常女性相比,P>0.05;对该位点的基因分布频率与乳腺癌雌激素受体(Er)表达状态进行分析后发现,等位基因T的频率在Er阳性乳腺癌患者中为43.93%,在正常女性中为34.67%,两者相比,P<0.05(Or为1.476)。结论 fgfr2基因第2内含子rS2981582位点的SnP与Er阳性乳腺癌的发生显著相关,携带等位基因T的个体患病风险增加。; Objective To study the relationship between single nucleotide polymorphism(SNP) of fibroblast growth factor receptors 2(FGFR2,rs2981582) and the susceptibility of breast cancer in Chinese women.Methods Case-control study was performed in 193 histological confirmed breast cancer cases and 150 cases of normal women as controls.rs2981582 of FGFR2 gene and its genetype were determined by PCR-direct sequencing.Results There were no significant differences in the allele frequencies of rs2981582 C/T of FGFR2 gene between cases and controls(P > 0.05).The gene frequency distribution and the expression of estrogen receptor(ER) in breast cancer were further analyzed.The minor allele T frequency of rs2981582 was 43.93% of cases whereas 34.67% of controls,the allele frequencies in the cases were significantly different from those of the controls(P < 0.05),the odds ratio(OR = 1.476) also showed a higher risk of breast cancer in individuals carrying the minor alleles.Conclusion The FGFR2 polymorphism rs2981582 C/T may contribute to the susceptibility of breast cancer with ER positive in Chinese women.; 国家自然科学基金资助项目(81173616); 福建省卫生厅青年科研课题(2009-2-78) |
| 语种 | zh_CN |
| 内容类型 | 期刊论文 |
| 源URL | [http://dspace.xmu.edu.cn/handle/2288/123402]  |
| 专题 | 药学院－已发表论文 |
| 推荐引用方式 GB/T 7714 | 付莉,陈双龙,黄红浪,等. FGFR2基因rs2981582位点单核苷酸多态性与乳腺癌易感性的关系, Relationship between polymorphism of fibroblast growth factor receptor 2 rs2981582 and susceptibility of breast cancer[J],2013. |
| APA | 付莉,陈双龙,黄红浪,骆伟珍,&范钦.(2013).FGFR2基因rs2981582位点单核苷酸多态性与乳腺癌易感性的关系.. |
| MLA | 付莉,et al."FGFR2基因rs2981582位点单核苷酸多态性与乳腺癌易感性的关系".(2013). |
| 个性服务 |
| 查看访问统计 |
| 相关权益政策 |
| 暂无数据 |
| 收藏/分享 |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论