Mechanism and factors that control HIV-1 transcription and latency activation

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	Mechanism and factors that control HIV-1 transcription and latency activation
	Liu, Rong-diao ; Wu, Jun ; Shao, Rui ; Xue, Yu-hua ; Xue YH(薛玉花)
刊名	http://dx.doi.org/10.1631/jzus.B1400059
	2014
关键词	RNA-POLYMERASE-II BROMODOMAIN PROTEIN BRD4 ELONGATION-FACTOR-B IMMUNODEFICIENCY-VIRUS TRANSCRIPTION P-TEFB 7SK SNRNA TAT-TRANSACTIVATION IN-VITRO C-MYC GENE-TRANSCRIPTION
英文摘要	National Natural Science Foundation of China [81201276]; Natural Science Foundation of Fujian Province, China [2012J05067]; After reverse transcription, the HIV-1 proviral DNA is integrated into the host genome and thus subjected to transcription by the host RNA polymerase II (Pol II). With the identification and characterization of human P-TEFb in the late 1990s as a specific host cofactor required for HIV-1 transcription, it is now believed that the elongation stage of Pol II transcription plays a particularly important role in regulating HIV-1 gene expression. HIV-1 uses a sophisticated scheme to recruit human P-TEFb and other cofactors to the viral long terminal repeat (LTR) to produce full-length HIV-1 transcripts. In this process, P-TEFb is regulated by the reversible association with various transcription factors/cofactors to form several multi-subunit complexes (e.g., 7SK snRNP, super elongation complexes (SECs), and the Brd4-P-TEFb complex) that collectively constitute a P-TEFb network for controlling cellular and HIV-1 transcription. Recent progresses in HIV-1 transcription were reviewed in the paper, with the emphasis on the mechanism and factors that control HIV-1 transcription and latency activation.
语种	英语
出版者	ZHEJIANG UNIV
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93079]
专题	药学院－已发表论文
推荐引用方式 GB/T 7714	Liu, Rong-diao,Wu, Jun,Shao, Rui,et al. Mechanism and factors that control HIV-1 transcription and latency activation[J]. http://dx.doi.org/10.1631/jzus.B1400059,2014.
APA	Liu, Rong-diao,Wu, Jun,Shao, Rui,Xue, Yu-hua,&薛玉花.(2014).Mechanism and factors that control HIV-1 transcription and latency activation.http://dx.doi.org/10.1631/jzus.B1400059.
MLA	Liu, Rong-diao,et al."Mechanism and factors that control HIV-1 transcription and latency activation".http://dx.doi.org/10.1631/jzus.B1400059 (2014).