Biomimetic RNA-Silencing Nanocomplexes: Overcoming Multidrug Resistance in Cancer Cells

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	Biomimetic RNA-Silencing Nanocomplexes: Overcoming Multidrug Resistance in Cancer Cells
	Wang, Zhongliang ; Wang, Zhe ; Liu, Dingbin ; Yan, Xuefeng ; Wang, Fu ; Niu, Gang ; Yang, Min ; Chen, Xiaoyuan ; Chen XY(陈小元)
刊名	http://dx.doi.org/10.1002/anie.201309985
	2014-02-10
关键词	MODIFIED GOLD NANOPARTICLES DELIVERY INTERFERENCE THERAPY SIRNA SIZE
英文摘要	National Natural Science Foundation [81171399, 81371596, 81101077]; CSC Foundation [2011832173]; National Significant New Drugs Creation Program [2012ZX09505-001-001]; National Basic Research Program of China (973 program) [2013CB733802, 2014CB744503]; Jiangsu Province Foundation [BK2011166, BE2012622, BL2012031, BM2012066]; Outstanding Professional Fund of Health Ministry in Jiangsu Province [RC2011095, H201028]; Intramural Research Program (IRP) of NIBIB/NIH; RNA interference (RNAi) is an RNA-dependent gene silencing approach controlled by an RNA-induced silencing complex (RISC). Herein, we present a synthetic RISC-mimic nanocomplex, which can actively cleave its target RNA in a sequence-specific manner. With high enzymatic stability and efficient self-delivery to target cells, the designed nanocomplex can selectively and potently induce gene silencing without cytokine activation. These nanocomplexes, which target multidrug resistance, are not only able to bypass the P-glycoprotein (Pgp) transporter, due to their nano-size effect, but also effectively suppress Pgp expression, thus resulting in successful restoration of drug sensitivity of OVCAR8/ADR cells to Pgp-transportable cytotoxic agents. This nanocomplex approach has the potential for both functional genomics and cancer therapy.
语种	英语
出版者	WILEY-V C H VERLAG GMBH
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/87593]
专题	公共卫生－已发表论文
推荐引用方式 GB/T 7714	Wang, Zhongliang,Wang, Zhe,Liu, Dingbin,et al. Biomimetic RNA-Silencing Nanocomplexes: Overcoming Multidrug Resistance in Cancer Cells[J]. http://dx.doi.org/10.1002/anie.201309985,2014.
APA	Wang, Zhongliang.,Wang, Zhe.,Liu, Dingbin.,Yan, Xuefeng.,Wang, Fu.,...&陈小元.(2014).Biomimetic RNA-Silencing Nanocomplexes: Overcoming Multidrug Resistance in Cancer Cells.http://dx.doi.org/10.1002/anie.201309985.
MLA	Wang, Zhongliang,et al."Biomimetic RNA-Silencing Nanocomplexes: Overcoming Multidrug Resistance in Cancer Cells".http://dx.doi.org/10.1002/anie.201309985 (2014).