Functional Magnetic Nanoparticles for Non-Viral Gene Delivery and MR Imaging

CORC > 厦门大学 > 公共卫生－已发表论文

	Functional Magnetic Nanoparticles for Non-Viral Gene Delivery and MR Imaging
	Xing, Ruijun ; Liu, Gang ; Zhu, Jinghan ; Hou, Yanglong ; Chen, Xiaoyuan ; Liu G(刘刚) ; Chen XY(陈小元)
刊名	http://dx.doi.org/10.1007/s11095-013-1205-2
	2014
关键词	IRON-OXIDE NANOPARTICLES SMALL INTERFERING RNA LOW-MOLECULAR-WEIGHT IN-VIVO DRUG-DELIVERY PAMAM DENDRIMERS BIOMEDICAL APPLICATIONS SURFACE MODIFICATION DNA DELIVERY TRANSFECTION EFFICIENCY
英文摘要	Major State Basic Research Development Program of China (973 Program) [2010-CB934601, 2013CB733802]; National Nature Science of Foundation of China (NSFC) [81101101, 51273165, 51125001, 51172005]; National Natural Science Foundation of China [51250110078]; Fundamental Research Funds for the Central Universities [2013121039]; Chinese Ministry of Education [212149]; Gene therapy is becoming a promising strategy to treat various kinds of genetic and acquired diseases. However, the development of safe, efficient, and targetable gene delivery systems remains a major challenge in gene therapy. The unique material characteristics of magnetic nanoparticles (MNPs), including high surface area, facile surface modification, controllable size, and excellent magnetic properties, make them promising candidates for gene delivery. The engineered MNPs with modifiable functional surfaces and bioactive cores can result in several advantageous diagnostic and therapeutic properties including enhanced magnetic resonance imaging (MRI) signal intensity, long permeation and retention in the circulatory system, specific delivery of therapeutic genes to target sites. In this review, the updated research on the preparation and surface modification of MNPs for gene delivery is summarized.
语种	英语
出版者	SPRINGER/PLENUM PUBLISHERS
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/87582]
专题	公共卫生－已发表论文
推荐引用方式 GB/T 7714	Xing, Ruijun,Liu, Gang,Zhu, Jinghan,et al. Functional Magnetic Nanoparticles for Non-Viral Gene Delivery and MR Imaging[J]. http://dx.doi.org/10.1007/s11095-013-1205-2,2014.
APA	Xing, Ruijun.,Liu, Gang.,Zhu, Jinghan.,Hou, Yanglong.,Chen, Xiaoyuan.,...&陈小元.(2014).Functional Magnetic Nanoparticles for Non-Viral Gene Delivery and MR Imaging.http://dx.doi.org/10.1007/s11095-013-1205-2.
MLA	Xing, Ruijun,et al."Functional Magnetic Nanoparticles for Non-Viral Gene Delivery and MR Imaging".http://dx.doi.org/10.1007/s11095-013-1205-2 (2014).