Dual-factor triggered fluorogenic nanoprobe for ultrahigh contrast and subdiffraction fluorescence imaging

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	Dual-factor triggered fluorogenic nanoprobe for ultrahigh contrast and subdiffraction fluorescence imaging
	Wang, Zhe ; Zhang, Xiaoxiang ; Huang, Peng ; Zhao, Weidong ; Liu, Dingbin ; Nie, Liming ; Yue, Xuyi ; Wang, Shouju ; Ma, Ying ; Kiesewetter, Dale ; Niu, Gang ; Chen, Xiaoyuan ; Chen XY(陈小元)
刊名	http://dx.doi.org/10.1016/j.biomaterials.2013.05.004
	2013
关键词	BODIPY DERIVATIVES NANOPARTICLES CELLS PROTEINS THERAPY SURGERY PROBES LIGHT DOTS DYES
英文摘要	National Basic Research Program of China (973 program) [2013CB733802]; Henry M. Jackson Foundation; NIBIB/NIH, U.S.A.; Ultrahigh contrast fluorescence molecular imaging has long been pursued over the past few decades from basic sciences to clinics. Although new classes of near-infrared (NIR) molecular probes are emerging, the requirement of fluorophores with high quantum yield, high signal to noise (S/N) ratio, and being activatable to microenvironment changes can hardly be fulfilled. In this study, a new NIR dye embedded fluorogenic nanoprobe (fg-nanoprobe) was developed for ultrahigh contrast in vitro and in vivo imaging with negligible background interference. The achieved S/N ratio was found to be attributed to the synergistic effects of the cellular compartmental triggered fluorogenicity and pH tunable fluorescence on/off character. In addition, this constructed fluorogenic nanoprobe could be coupled with image processing method for super-resolution subdiffraction imaging. The developed fg-nanoprobe integrated photophysical merits of the synthesized NIR fluorophore and advantages of engineered nanoparticle for enhanced fluorescence molecular imaging. This probe may open another avenue for ultrahigh contrast fluorescence molecular imaging in the future. Published by Elsevier Ltd.
语种	英语
出版者	ELSEVIER SCI LTD
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/87577]
专题	公共卫生－已发表论文
推荐引用方式 GB/T 7714	Wang, Zhe,Zhang, Xiaoxiang,Huang, Peng,et al. Dual-factor triggered fluorogenic nanoprobe for ultrahigh contrast and subdiffraction fluorescence imaging[J]. http://dx.doi.org/10.1016/j.biomaterials.2013.05.004,2013.
APA	Wang, Zhe.,Zhang, Xiaoxiang.,Huang, Peng.,Zhao, Weidong.,Liu, Dingbin.,...&陈小元.(2013).Dual-factor triggered fluorogenic nanoprobe for ultrahigh contrast and subdiffraction fluorescence imaging.http://dx.doi.org/10.1016/j.biomaterials.2013.05.004.
MLA	Wang, Zhe,et al."Dual-factor triggered fluorogenic nanoprobe for ultrahigh contrast and subdiffraction fluorescence imaging".http://dx.doi.org/10.1016/j.biomaterials.2013.05.004 (2013).