Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody

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	Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody
	McLellan, Jason S. ; Chen, Man ; Leung, Sherman ; Graepel, Kevin W. ; Du, Xiulian ; Yang, Yongping ; Zhou, Tongqing ; Baxa, Ulrich ; Yasuda, Etsuko ; Beaumont, Tim ; Kumar, Azad ; Modjarrad, Kayvon ; Zheng, Zizheng ; Zhao, Min ; Xia, Ningshao ; Kwong, Peter D. ; Gr ; Zheng ZZ(郑子峥) ; Xia NS(夏宁邵)
刊名	http://dx.doi.org/10.1126/science.1234914
	2013
关键词	RESPIRATORY SYNCYTIAL VIRUS MONOCLONAL-ANTIBODY F-GLYCOPROTEIN PROTEIN INFECTION EPITOPES CONFORMATION MOTAVIZUMAB CHILDREN SEQUENCE
英文摘要	Intramural Research Program (National Institute of Allergy and Infectious Diseases); National Natural Science Foundation of China [81161120419]; U.S. Department of Energy, Basic Energy Sciences, Office of Science [W-31-109-Eng-38]; The prefusion state of respiratory syncytiat virus (RSV) fusion (F) glycoprotein is the target of most RSV-neutralizing activity in human sera, but its metastability has hindered characterization. To overcome this obstacle, we identified prefusion-specific antibodies that were substantially more potent than the prophylactic antibody palivizumab. The cocrystal structure for one of these antibodies, D25, in complex with the F glycoprotein revealed D25 to lock F in its prefusion state by binding to a quaternary epitope at the trimer apex. Electron microscopy showed that two other antibodies, AM22 and 5C4, also bound to the newly identified site of vulnerability, which we named antigenic site empty set. These studies should enable design of improved vaccine antigens and define new targets for passive prevention of RSV-induced disease,
语种	英语
出版者	AMER ASSOC ADVANCEMENT SCIENCE
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/87567]
专题	公共卫生－已发表论文
推荐引用方式 GB/T 7714	McLellan, Jason S.,Chen, Man,Leung, Sherman,et al. Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody[J]. http://dx.doi.org/10.1126/science.1234914,2013.
APA	McLellan, Jason S..,Chen, Man.,Leung, Sherman.,Graepel, Kevin W..,Du, Xiulian.,...&夏宁邵.(2013).Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody.http://dx.doi.org/10.1126/science.1234914.
MLA	McLellan, Jason S.,et al."Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody".http://dx.doi.org/10.1126/science.1234914 (2013).