Ferritin Nanocages To Encapsulate and Deliver Photosensitizers for Efficient Photodynamic Therapy against Cancer

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	Ferritin Nanocages To Encapsulate and Deliver Photosensitizers for Efficient Photodynamic Therapy against Cancer
	Zhen, Zipeng ; Tang, Wei ; Guo, Cunlan ; Chen, Hongmin ; Lin, Xin ; Liu, Gang ; Fei, Baowei ; Chen, Xiaoyuan ; Xu, Binqian ; Xie, Jin ; Liu G(刘刚)
刊名	http://dx.doi.org/10.1021/nn402199g
	2013
关键词	ZINC PHTHALOCYANINE PROSTATE-CANCER COMBINATION THERAPY DRUG-DELIVERY NANOPARTICLES APOFERRITIN TUMORS GROWTH MODEL
英文摘要	NCl/NIH [5R00CA153772, R01CA156775]; UGA; U.S. National Science Foundation [ECCS0823849, CBET 1139057]; Georgia Cancer Coalition Distinguished Clinicians and Scientists Award; Intramural Research Program of NIBIB; NIH; Major State Basic Research Development Program of China (973 Program) [2013CB733802]; National Nature Science of Foundation of China (NSFC) [81101101, 51273165]; Key Project of Chinese Ministry of Education [212149]; Photodynamic therapy is an emerging treatment modality that is under, intensive preclinical and clinical investigations for many types of disease including cancer. Despite the promise, there is a lack of a reliable drug delivery vehicle that can transport photosensitizers (PSs) to tumors in a site-specific manner: Previous efforts have been focused on polymer- or liposome-based nanocarriers, which are usually associated with a suboptimal PS loading rate and a large particle size. We report herein that a RGD4C-modified ferritin (RFRT), a protein-based nanoparticle, can serve as a safe and efficient PS vehicle. Zinc hexadecafluorophthalocyanine (ZnF16Pc), a potent PS with a high 102 quantum yield but poor water solubility, can be encapsulated into RFRTs with a loading rate as high as similar to 60 wt % (i.e, 13 mg of ZnF16Pc can be loaded on 1 mg of RAM), which far exceeds those reported previously.. Despite the high loading, the ZnF16Pc-loaded Fans (P-RFRTs) show an overall particle size of 18.6 +/- 2.6 nm, which is significantly smaller than other PS-nanocarrier conjugates: When tested on U87MG subcutaneous tumor models, P-RFRTs showed a high tumor accumulation rate (tumor-to-normal tissue ratio of 26.82 +/- 4.07at 24 h), a good tumor inhibition rate (8164% on day 12), as well as minimal toxicity to the skin and other major organs. This technology can be extended to deliver other metal-containing PSs and holds great clinical translation potential.
语种	英语
出版者	AMER CHEMICAL SOC
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/87560]
专题	公共卫生－已发表论文
推荐引用方式 GB/T 7714	Zhen, Zipeng,Tang, Wei,Guo, Cunlan,et al. Ferritin Nanocages To Encapsulate and Deliver Photosensitizers for Efficient Photodynamic Therapy against Cancer[J]. http://dx.doi.org/10.1021/nn402199g,2013.
APA	Zhen, Zipeng.,Tang, Wei.,Guo, Cunlan.,Chen, Hongmin.,Lin, Xin.,...&刘刚.(2013).Ferritin Nanocages To Encapsulate and Deliver Photosensitizers for Efficient Photodynamic Therapy against Cancer.http://dx.doi.org/10.1021/nn402199g.
MLA	Zhen, Zipeng,et al."Ferritin Nanocages To Encapsulate and Deliver Photosensitizers for Efficient Photodynamic Therapy against Cancer".http://dx.doi.org/10.1021/nn402199g (2013).