Virus-like particle-based human vaccines: quality assessment based on structural and functional properties

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	Virus-like particle-based human vaccines: quality assessment based on structural and functional properties
	Zhao, Qinjian ; Li, Shaowei ; Yu, Hai ; Xia, Ningshao ; Modis, Yorgo ; Zhao QJ(赵勤俭) ; Li SW(李少伟) ; Yu H(俞海) ; Xia NS(夏宁邵)
刊名	http://dx.doi.org/10.1016/j.tibtech.2013.09.002
	2013
关键词	HEPATITIS-E VIRUS DIFFERENTIAL MOBILITY ANALYSIS SURFACE-ANTIGEN PARTICLES NEUTRALIZING MONOCLONAL-ANTIBODIES LINKED-IMMUNOSORBENT-ASSAY FIELD-FLOW FRACTIONATION IN-VITRO POTENCY B-VACCINE BOVINE PAPILLOMAVIRUS MUTATIONAL ANALYSIS
英文摘要	Institute Reconstruction Fund [2011FU125Z04]; National science Foundation of China [81172885, 81273327]; Xiamen City Municipal platform fund on viral biotherapeutics [3502Z20131001]; Burroughs Wellcome Investigator Award; Human vaccines against three viruses use recombinant virus-like particles (VLPs) as the antigen: hepatitis B virus, human papillomavirus, and hepatitis E virus. VLPs are excellent prophylactic vaccine antigens because they are self-assembling bionanoparticles (20 to 60 nm in diameter) that expose multiple epitopes on their surface and faithfully mimic the native virions. Here we summarize the long journey of these vaccines from bench to patients. The physical properties and structural features of each recombinant VLP vaccine are described. With the recent licensure of Hecolin against hepatitis E virus adding a third disease indication to prophylactic VLP-based vaccines, we review how the crucial quality attributes of VLP-based human vaccines against all three disease indications were assessed, controlled, and improved during bioprocessing through an array of structural and functional analyses.
语种	英语
出版者	ELSEVIER SCIENCE LONDON
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/87554]
专题	公共卫生－已发表论文
推荐引用方式 GB/T 7714	Zhao, Qinjian,Li, Shaowei,Yu, Hai,et al. Virus-like particle-based human vaccines: quality assessment based on structural and functional properties[J]. http://dx.doi.org/10.1016/j.tibtech.2013.09.002,2013.
APA	Zhao, Qinjian.,Li, Shaowei.,Yu, Hai.,Xia, Ningshao.,Modis, Yorgo.,...&夏宁邵.(2013).Virus-like particle-based human vaccines: quality assessment based on structural and functional properties.http://dx.doi.org/10.1016/j.tibtech.2013.09.002.
MLA	Zhao, Qinjian,et al."Virus-like particle-based human vaccines: quality assessment based on structural and functional properties".http://dx.doi.org/10.1016/j.tibtech.2013.09.002 (2013).