Effect of Centella asiatica on Oxidative Stress and Lipid Metabolism in Hyperlipidemic Animal Models

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	Effect of Centella asiatica on Oxidative Stress and Lipid Metabolism in Hyperlipidemic Animal Models
	Zhao, Yun ; Shu, Ping ; Zhang, Youzhi ; Lin, Limin ; Zhou, Haihong ; Xu, Zhentian ; Suo, Daqin ; Xie, Anzhi ; Jin, Xin ; Zhao Y(赵云) ; Zhou HH(周海虹) ; Jin X(金鑫)
刊名	http://dx.doi.org/10.1155/2014/154295
	2014
关键词	HIGH-FAT DIET CHOLESTEROL LEVELS SR-BI RATS HAMSTERS DYSLIPIDEMIA EXTRACT DISEASE LIVER
英文摘要	Research Fund of Strait (Xiamen) Technology Platform in Traditional Chinese Medicine [3502Z20100006]; Hyperlipidemia and many other metabolic diseases are related to oxidative stress. Centella asiatica is a traditional Chinese medicine whose antioxidant effect in vitro has been reported. We are interested in whether it possesses this effect in vivo and hence modulates lipid metabolism. Therefore, experiments were carried out on mice and golden hamsters regarding its antioxidant and hypolipidemic effect. We observed that a fraction (CAF3) of the ethanol extract (CAE) of Centella asiatica had a cholesterol decrease of 79% and a triglyceride decrease of 95% in acute mice model, so CAF3 was further investigated in high-fat-fed hamster model. It was shown that CAF3 increased SOD and GSH-Px activities and decreased MDA level, and it also improved TC, TG, LDL-C, HDL-C, AST, and ALT levels. L-CAT and SR-BI gene expression in hamsters were increased. Taken together, our data suggest that the CAF3 fraction of Centella asiatica has antioxidant and hypolipidemic properties.
语种	英语
出版者	HINDAWI PUBLISHING CORPORATION
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93703]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Zhao, Yun,Shu, Ping,Zhang, Youzhi,et al. Effect of Centella asiatica on Oxidative Stress and Lipid Metabolism in Hyperlipidemic Animal Models[J]. http://dx.doi.org/10.1155/2014/154295,2014.
APA	Zhao, Yun.,Shu, Ping.,Zhang, Youzhi.,Lin, Limin.,Zhou, Haihong.,...&金鑫.(2014).Effect of Centella asiatica on Oxidative Stress and Lipid Metabolism in Hyperlipidemic Animal Models.http://dx.doi.org/10.1155/2014/154295.
MLA	Zhao, Yun,et al."Effect of Centella asiatica on Oxidative Stress and Lipid Metabolism in Hyperlipidemic Animal Models".http://dx.doi.org/10.1155/2014/154295 (2014).