Pre-treatment Metabolic Tumor Volume and Total Lesion Glycolysis are Useful Prognostic Factors for Esophageal Squamous Cell Cancer Patients

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	Pre-treatment Metabolic Tumor Volume and Total Lesion Glycolysis are Useful Prognostic Factors for Esophageal Squamous Cell Cancer Patients
	Li, Yi-Min ; Lin, Qin ; Zhao, Long ; Wang, Li-Chen ; Sun, Long ; Dai, Ming-Ming ; Luo, Zuo-Ming ; Zheng, Hua ; Wu, Hua ; Lin Q(林勤) ; Sun L(孙龙) ; Wu H(吴华)
刊名	http://dx.doi.org/10.7314/APJCP.2014.15.3.1369
	2014
关键词	POSITRON-EMISSION-TOMOGRAPHY FDG-PET LUNG-CANCER CARCINOMA SURVIVAL CHEMORADIOTHERAPY ADENOCARCINOMA RADIOTHERAPY PARAMETERS
英文摘要	Major Projects of Fujian Natural Science Foundation [2008-59-11]; Nature Science Foundation of China [81101066]; Objectives: To study application of the maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) with F-18-FDG PET/CT for predicting prognosis of esophageal squamous cell cancer (ESC) patients. Methods: Eighty-six patients with ESC staged from I to IV were prospectively enrolled. Cisplatin-based chemoradiotherapy (CCRT) or palliative chemoradiotherapy were the main treatment methods and none received surgery. F-18-FDG PET/CT scans were performed before the treatment. SUVmax, MTV, and TLG were measured for the primary esophageal lesion and regional lymph nodes. Receiver operating characteristic curves (ROCs) were generated to calculate the P value of the predictive ability and the optimal threshold. Results: MTV and TLG proved to be good indexes in the prediction of outcome for the ESC patients. An MTV value of 15.6 ml and a TLG value of 183.5 were optimal threshold to predict the overall survival (OS). The areas under the curve (AUC) for MTV and TLG were 0.74 and 0.70, respectively. Kaplan-Meier analysis showed an MTV less than 15.6 ml and a TLG less than 183.5 to indicate good media survival time (p value <0.05). In the stage III-IV patient group, MTV could better predict the OS (P < 0.001), with a sensitivity and specificity of 0.80 and 0.67, respectively. Conclusions: Pre-treatment MTV and TLG are useful prognostic factors in non-surgical ESC.
语种	英语
出版者	ASIAN PACIFIC ORGANIZATION CANCER PREVENTION
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93702]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Li, Yi-Min,Lin, Qin,Zhao, Long,et al. Pre-treatment Metabolic Tumor Volume and Total Lesion Glycolysis are Useful Prognostic Factors for Esophageal Squamous Cell Cancer Patients[J]. http://dx.doi.org/10.7314/APJCP.2014.15.3.1369,2014.
APA	Li, Yi-Min.,Lin, Qin.,Zhao, Long.,Wang, Li-Chen.,Sun, Long.,...&吴华.(2014).Pre-treatment Metabolic Tumor Volume and Total Lesion Glycolysis are Useful Prognostic Factors for Esophageal Squamous Cell Cancer Patients.http://dx.doi.org/10.7314/APJCP.2014.15.3.1369.
MLA	Li, Yi-Min,et al."Pre-treatment Metabolic Tumor Volume and Total Lesion Glycolysis are Useful Prognostic Factors for Esophageal Squamous Cell Cancer Patients".http://dx.doi.org/10.7314/APJCP.2014.15.3.1369 (2014).