Trafficking regulation of proteins in Alzheimer's disease

CORC > 厦门大学 > 医学院－已发表论文

	Trafficking regulation of proteins in Alzheimer's disease
	Jiang, Shangtong ; Li, Yanfang ; Zhang, Xian ; Bu, Guojun ; Xu, Huaxi ; Zhang, Yun-wu ; Bu GJ(卜国军) ; Xu HX(许华曦) ; Zhang YW(张云武)
刊名	http://dx.doi.org/10.1186/1750-1326-9-6
	2014-01-11
关键词	AMYLOID PRECURSOR PROTEIN TRANS-GOLGI NETWORK GAMMA-SECRETASE ACTIVITY SORTILIN-RELATED RECEPTOR BETA PEPTIDE GENERATION NECROSIS-FACTOR-ALPHA INTRACELLULAR TRAFFICKING ENDOPLASMIC-RETICULUM APOLIPOPROTEIN-E CLEAVING ENZYME
英文摘要	National Institutes of Health [R01AG038710, R01AG021173, R01AG044420, R01NS046673]; Alzheimer's Association; National Natural Science Foundation of China [81225008, 81000540, 81161120496, 91332112, 91332114]; Fundamental Research Funds for the Central Universities of China; Fok Ying Tung Education Foundation; The beta-amyloid (A beta) peptide has been postulated to be a key determinant in the pathogenesis of Alzheimer's disease (AD). A beta is produced through sequential cleavage of the beta-amyloid precursor protein (APP) by beta-and gamma-secretases. APP and relevant secretases are transmembrane proteins and traffic through the secretory pathway in a highly regulated fashion. Perturbation of their intracellular trafficking may affect dynamic interactions among these proteins, thus altering A beta generation and accelerating disease pathogenesis. Herein, we review recent progress elucidating the regulation of intracellular trafficking of these essential protein components in AD.
语种	英语
出版者	BIOMED CENTRAL LTD
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93690]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Jiang, Shangtong,Li, Yanfang,Zhang, Xian,et al. Trafficking regulation of proteins in Alzheimer's disease[J]. http://dx.doi.org/10.1186/1750-1326-9-6,2014.
APA	Jiang, Shangtong.,Li, Yanfang.,Zhang, Xian.,Bu, Guojun.,Xu, Huaxi.,...&张云武.(2014).Trafficking regulation of proteins in Alzheimer's disease.http://dx.doi.org/10.1186/1750-1326-9-6.
MLA	Jiang, Shangtong,et al."Trafficking regulation of proteins in Alzheimer's disease".http://dx.doi.org/10.1186/1750-1326-9-6 (2014).