miRNA423-5p regulates cell proliferation and invasion by targeting trefoil factor 1 in gastric cancer cells

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	miRNA423-5p regulates cell proliferation and invasion by targeting trefoil factor 1 in gastric cancer cells
	Liu, Jingjing ; Wang, Xu ; Yang, Xiaoning ; Liu, Yunpeng ; Shi, Ying ; Ren, Jianlin ; Guleng, Bayasi ; Ren JL(任建林) ; 巴亚斯古楞
刊名	http://dx.doi.org/10.1016/j.canlet.2014.01.024
	2014-05-28
关键词	EPITHELIAL-CELLS GROWTH-FACTOR PS2 GENE PEPTIDES EXPRESSION MICRORNAS TFF1 MIGRATION STOMACH REGION
英文摘要	National Natural Science Foundation of China [81101817, 81370591, 30971362]; Foundations of Health Bureau of Fujian and Xiamen in China [3502Z200940010]; TFF1 is a small, secreted protein in the TFF family that has a pivotal role as a motogenic factor in epithelial restitution and cell motility, and as a tumor suppressor gene in the stomach. In this study, we identified TFF1 as a novel target gene of miRNA-423-5p. miRNA-423-5p negatively regulated the expression of TFF1 by binding to its 3'UTR and participated in proliferation/invasion-related processes via a TFF1-dependent manner in gastric cancer cells. Our findings suggested that miR-423-5p may be a novel target for the future development of specific therapeutic interventions for gastric cancer. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
语种	英语
出版者	ELSEVIER IRELAND LTD
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93608]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Liu, Jingjing,Wang, Xu,Yang, Xiaoning,et al. miRNA423-5p regulates cell proliferation and invasion by targeting trefoil factor 1 in gastric cancer cells[J]. http://dx.doi.org/10.1016/j.canlet.2014.01.024,2014.
APA	Liu, Jingjing.,Wang, Xu.,Yang, Xiaoning.,Liu, Yunpeng.,Shi, Ying.,...&巴亚斯古楞.(2014).miRNA423-5p regulates cell proliferation and invasion by targeting trefoil factor 1 in gastric cancer cells.http://dx.doi.org/10.1016/j.canlet.2014.01.024.
MLA	Liu, Jingjing,et al."miRNA423-5p regulates cell proliferation and invasion by targeting trefoil factor 1 in gastric cancer cells".http://dx.doi.org/10.1016/j.canlet.2014.01.024 (2014).