Does prolonged pituitary down-regulation with gonadotropin-releasing hormone agonist improve the live-birth rate in in vitro fertilization treatment?

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	Does prolonged pituitary down-regulation with gonadotropin-releasing hormone agonist improve the live-birth rate in in vitro fertilization treatment?
	Ren, Jianzhi ; Sha, Aiguo ; Han, Dongmei ; Li, Ping ; Geng, Jie ; Ma, Chaihui ; Geng J(耿洁)
刊名	http://dx.doi.org/10.1016/j.fertnstert.2014.03.030
	2014
关键词	EMBRYO-TRANSFER CYCLES GNRH-AGONIST OVARIAN STIMULATION ENDOMETRIAL THICKNESS ASSISTED REPRODUCTION INVITRO FERTILIZATION PROFOUND SUPPRESSION LUTEINIZING-HORMONE UTERINE RECEPTIVITY ANTAGONIST CYCLES
英文摘要	Xiamen City [3502z20111006]; Objective: To evaluate the effects of a prolonged duration of gonadotropin-releasing hormone agonist (GnRH-a) in pituitary down-regulation for controlled ovarian hyperstimulation (COH) on the live-birth rate in nonendometriotic women undergoing in vitro fertilization and embryo transfer (IVF-ET). Design: Retrospective cohort study. Setting: University-affiliated hospital. Patient(s): Normogonadotropic women undergoing IVF. Intervention(s): Three hundred seventy-eight patients receiving a prolonged pituitary down-regulation with GnRH-a before ovarian stimulation and 422 patients receiving a GnRH-a long protocol. Main Outcome Measure(s): Live-birth rate per fresh ET. Result(s): In comparison with the long protocol, the prolonged down-regulation protocol required a higher total dose of gonadotropins. A lower serum luteinizing hormone (LH) level on the starting day of gonadotropin and the day of human chorionic gonadotropin (hCG) and a fewer number of oocytes and embryos were observed in the prolonged down-regulation protocol. However, the duration of stimulation and number of high-quality embryos were comparable between the two groups. A statistically significantly higher implantation rate (50.27% vs. 39.69%), clinical pregnancy rate (64.02% vs. 56.87%) and live-birth rate per fresh transfer cycle (55.56% vs. 45.73%) were observed in the prolonged protocol. Conclusion(s): Prolonged down-regulation in a GnRH-a protocol might increase the live-birth rates in normogonadotropic women. (C) 2014 by American Society for Reproductive Medicine.
语种	英语
出版者	ELSEVIER SCIENCE INC
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93587]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Ren, Jianzhi,Sha, Aiguo,Han, Dongmei,et al. Does prolonged pituitary down-regulation with gonadotropin-releasing hormone agonist improve the live-birth rate in in vitro fertilization treatment?[J]. http://dx.doi.org/10.1016/j.fertnstert.2014.03.030,2014.
APA	Ren, Jianzhi.,Sha, Aiguo.,Han, Dongmei.,Li, Ping.,Geng, Jie.,...&耿洁.(2014).Does prolonged pituitary down-regulation with gonadotropin-releasing hormone agonist improve the live-birth rate in in vitro fertilization treatment?.http://dx.doi.org/10.1016/j.fertnstert.2014.03.030.
MLA	Ren, Jianzhi,et al."Does prolonged pituitary down-regulation with gonadotropin-releasing hormone agonist improve the live-birth rate in in vitro fertilization treatment?".http://dx.doi.org/10.1016/j.fertnstert.2014.03.030 (2014).