Prognostic significance of annexin II expression in non-small cell lung cancer

CORC > 厦门大学 > 医学院－已发表论文

	Prognostic significance of annexin II expression in non-small cell lung cancer
	Luo, C. -H. ; Liu, Q. -Q. ; Zhang, P. -F. ; Li, M. -Y. ; Chen, Z. -C. ; Liu, Y. -F. ; Liu YF(刘迎福)
刊名	http://dx.doi.org/10.1007/s12094-013-1028-y
	2013
关键词	DIFFERENCE GEL-ELECTROPHORESIS PROTEOMIC ANALYSIS CARCINOMA CELLS PANCREATIC-CANCER MASS-SPECTROMETRY PROSTATE-CANCER COLON-CANCER METASTASIS PROTEINS TUMOR
英文摘要	National Key Basic Research Program of China [2001CB510207]; National Natural Science Funds of China [81101764]; Fundamental Research Funds for the Central Universities [2010121104]; Natural Science Foundation of Fujian Province of China [2011J05099]; To discover common metastasis-related and prognostic markers in lung squamous carcinoma (LSC) and lung adenocarcinoma (AdC), two forms of non-small cell lung cancer (NSCLC). Quantitative proteomic analysis was performed between primary cancer tissues and matched lymph node metastatic tissues in LSC and AdC, respectively. Immunohistochemistry and statistic analysis were performed to investigate prognostic significance of metastasis-related protein annexin II expression in LSC and AdC. Both in LSC and AdC, elevated expression of annexin II was identified in lymph node metastatic lung cancers compared to corresponding primary lung cancers. Furthermore, immunohistochemical analysis of a bulk of clinical specimens indicated that annexin II over-expression was more frequently observed in matched lymph node metastatic tissues than corresponding primary cancer tissues. Statistical analysis showed that annexin II over-expression was significantly associated with advanced clinical stage (P < 0.05) and lymph node metastasis (P < 0.05) and increased relapse rate (P < 0.05) and decreased overall survival (P < 0.05) in both two subtypes of NSCLC. Cox regression analysis indicated that annexin II over-expression was an important prognostic factor in both LSC and AdC. Annexin II was identified as a common prognostic factor in both LSC and AdC.
语种	英语
出版者	SPRINGER-VERLAG ITALIA SRL
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93465]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Luo, C. -H.,Liu, Q. -Q.,Zhang, P. -F.,et al. Prognostic significance of annexin II expression in non-small cell lung cancer[J]. http://dx.doi.org/10.1007/s12094-013-1028-y,2013.
APA	Luo, C. -H..,Liu, Q. -Q..,Zhang, P. -F..,Li, M. -Y..,Chen, Z. -C..,...&刘迎福.(2013).Prognostic significance of annexin II expression in non-small cell lung cancer.http://dx.doi.org/10.1007/s12094-013-1028-y.
MLA	Luo, C. -H.,et al."Prognostic significance of annexin II expression in non-small cell lung cancer".http://dx.doi.org/10.1007/s12094-013-1028-y (2013).