Berberine potently attenuates intestinal polyps growth in ApcMin mice and familial adenomatous polyposis patients through inhibition of Wnt signalling

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	Berberine potently attenuates intestinal polyps growth in ApcMin mice and familial adenomatous polyposis patients through inhibition of Wnt signalling
	Zhang, Junfang ; Cao, Hailong ; Zhang, Bing ; Cao, Hanwei ; Xu, Xiuqin ; Ruan, Hang ; Yi, Tingting ; Tan, Li ; Qu, Rui ; Song, Gang ; Wang, Bangmao ; Hu, Tianhui ; Zhang B(张兵) ; Xu XQ(徐秀琴) ; Song G(宋刚) ; Hu TH(胡天惠)
刊名	http://dx.doi.org/10.1111/jcmm.12119
	2013
关键词	HUMAN COLORECTAL-CANCER BETA-CATENIN CELL-GROWTH STEM-CELLS APOPTOSIS PATHWAY TUMORIGENESIS RECEPTORS CYCLOOXYGENASE-2 CARCINOGENESIS
英文摘要	Natural Science Foundation of Fujian [2010J0615]; National Natural Science Foundation of China [81172284, 81272721, 31071187, 81070283, 81072015]; Ministry of Science and Technology [2009CB522200]; 985 Project grant of Xiamen University [2010121103]; Xiamen Science and Technology Key program [3502Z20100006]; As a traditional anti-inflammatory Chinese herbal medicine, Alkaloid berberine has been recently reported to exhibit anti-tumour effects against a wide spectrum of cancer. However, the mechanism was largely unknown. Gene chip array reveals that with berberine treatment, c-Myc, the target gene of Wnt pathway, was down-regulated 5.3-folds, indicating that berberine might inhibit Wnt signalling. TOPflash analysis revealed that Wnt activity was significantly reduced after berberine treatment, and the mechanism of which might be that berberine disrupted -catenin transfer to nucleus through up-regulating the expression of adenomatous polyposis coli (APC) gene and stabilized APC--catenin complex. Berberine administration in ApcMin/+ mice exhibited fewer and smaller polyps in intestine, along with reduction in cyclin D1 and c-Myc expression. In clinical practice, oral administration of berberine also significantly reduced the familial adenomatous polyposis patients' polyp size along with the inhibition of cyclin D1 expression in polyp samples. These observations indicate that berberine inhibits colon tumour formation through inhibition of Wnt/-catenin signalling and berberine might be a promising drug for the prevention of colon cancer.
语种	英语
出版者	WILEY-BLACKWELL
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93454]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Zhang, Junfang,Cao, Hailong,Zhang, Bing,et al. Berberine potently attenuates intestinal polyps growth in ApcMin mice and familial adenomatous polyposis patients through inhibition of Wnt signalling[J]. http://dx.doi.org/10.1111/jcmm.12119,2013.
APA	Zhang, Junfang.,Cao, Hailong.,Zhang, Bing.,Cao, Hanwei.,Xu, Xiuqin.,...&胡天惠.(2013).Berberine potently attenuates intestinal polyps growth in ApcMin mice and familial adenomatous polyposis patients through inhibition of Wnt signalling.http://dx.doi.org/10.1111/jcmm.12119.
MLA	Zhang, Junfang,et al."Berberine potently attenuates intestinal polyps growth in ApcMin mice and familial adenomatous polyposis patients through inhibition of Wnt signalling".http://dx.doi.org/10.1111/jcmm.12119 (2013).