Oxidative stress disturbs energy metabolism of mitochondria in ethanol-induced gastric mucosa injury

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	Oxidative stress disturbs energy metabolism of mitochondria in ethanol-induced gastric mucosa injury
	Pan, Jin-Shui ; He, Shao-Zhen ; Xu, Hong-Zhi ; Zhan, Xiao-Juan ; Yang, Xiao-Ning ; Xiao, Hong-Min ; Shi, Hua-Xiu ; Ren, Jian-Lin ; Pan JS(潘金水) ; Xu HZ(许鸿志) ; Shi HX(施华秀) ; Ren JL(任建林)
刊名	http://dx.doi.org/10.3748/wjg.14.5857
	2008-10-14
关键词	HYDROGEN-PEROXIDE ATP SYNTHASE DNA DAMAGE LESIONS CELLS RAT DYSFUNCTION MUTATION ALCOHOL MUSCLE
英文摘要	AIM: To study the role of mitochondrial energy disorder in the pathogenesis of ethanol-induced gastric mucosa injury. METHODS: Wistar rats were used in this study. A gastric mucosal injury model was established by giving the rats alcohol. Gross and microscopic appearance of gastric mucosa and ultrastructure of mitochondria were evaluated. Malondiadehyde (MDA) in gastric mucosa was measured with thiobarbituric acid. Expression of ATP synthase (ATPase) subunits 6 and 8 in mitochondrial DNA (mtDNA) was determined by reverse transcription polymerase chain reaction (RTPCR). RESULTS: The gastric mucosal lesion index was correlated with the MDA content in gastric mucosa. As the concentration of ethanol was elevated and the exposure time to ethanol was extended, the content of MDA in gastric mucosa increased and the extent of damage aggravated. The ultrastructure of mitochondria was positively related to the ethanol concentration and exposure time. The expression of mtDNA ATPase subunits 6 and 8 mRNA declined with the increasing MDA content in gastric mucosa after gavage with ethanol. CONCLUSION: Ethanol-induced gastric mucosa injury is related to oxidative stress, which disturbs energy metabolism of mitochondria and plays a critical role in the pathogenesis of ethanol-induced gastric mucosa injury. (C) 2008 The WIG Press. All rights reserved.
语种	英语
出版者	WORLD J GASTROENTERO
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93375]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Pan, Jin-Shui,He, Shao-Zhen,Xu, Hong-Zhi,et al. Oxidative stress disturbs energy metabolism of mitochondria in ethanol-induced gastric mucosa injury[J]. http://dx.doi.org/10.3748/wjg.14.5857,2008.
APA	Pan, Jin-Shui.,He, Shao-Zhen.,Xu, Hong-Zhi.,Zhan, Xiao-Juan.,Yang, Xiao-Ning.,...&任建林.(2008).Oxidative stress disturbs energy metabolism of mitochondria in ethanol-induced gastric mucosa injury.http://dx.doi.org/10.3748/wjg.14.5857.
MLA	Pan, Jin-Shui,et al."Oxidative stress disturbs energy metabolism of mitochondria in ethanol-induced gastric mucosa injury".http://dx.doi.org/10.3748/wjg.14.5857 (2008).