The Silencing of Pokemon Attenuates the Proliferation of Hepatocellular Carcinoma Cells In Vitro and In Vivo by Inhibiting the PI3K/Akt Pathway

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	The Silencing of Pokemon Attenuates the Proliferation of Hepatocellular Carcinoma Cells In Vitro and In Vivo by Inhibiting the PI3K/Akt Pathway
	Lin, Chan-Chan ; Zhou, Jing-Ping ; Liu, Yun-Peng ; Liu, Jing-Jing ; Yang, Xiao-Ning ; Jazag, Amarsanaa ; Zhang, Zhi-Ping ; Guleng, Bayasi ; Ren, Jian-Lin ; Ren JL(任建林)
刊名	http://dx.doi.org/10.1371/journal.pone.0051916
	2012-12-26
关键词	REPRESSES TRANSCRIPTION NUCLEAR-LOCALIZATION TUMOR SUPPRESSION POOR-PROGNOSIS FBI-1 ACTIVATION GENE EXPRESSION PROTEIN GROWTH
英文摘要	Youth Innovation Fund of Fujian Province [2006F3127]; National Natural Science Foundation of China [30971362, 81072013]; Fundamental Research Funds for the Central Universities in China [2010111082]; Pokemon (POK erythroid myeloid ontogenic factor), which belongs to the POK protein family, is also called LRF, OCZF and FBI-1. As a transcriptional repressor, Pokemon assumes a critical function in cellular differentiation and oncogenesis. Our study identified an oncogenic role for Pokemon in human hepatocellular carcinoma (HCC). We successfully established human HepG2 and Huh-7 cell lines in which Pokemon was stably knocked down. We demonstrated that Pokemon silencing inhibited cell proliferation and migration. Pokemon knockdown inhibited the PI3K/Akt and c-Raf/MEK/ERK pathways and modulated the expression of various cell cycle regulators in HepG2 and Huh-7 cells. Therefore, Pokemon may also be involved in cell cycle progression in these cells. We confirmed that Pokemon silencing suppresses hepatocellular carcinoma growth in tumor xenograft mice. These results suggest that Pokemon promotes cell proliferation and migration in hepatocellular carcinoma and accelerates tumor development in an Akt- and ERK-signaling-dependent manner.
语种	英语
出版者	PLOS ONE
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93329]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Lin, Chan-Chan,Zhou, Jing-Ping,Liu, Yun-Peng,et al. The Silencing of Pokemon Attenuates the Proliferation of Hepatocellular Carcinoma Cells In Vitro and In Vivo by Inhibiting the PI3K/Akt Pathway[J]. http://dx.doi.org/10.1371/journal.pone.0051916,2012.
APA	Lin, Chan-Chan.,Zhou, Jing-Ping.,Liu, Yun-Peng.,Liu, Jing-Jing.,Yang, Xiao-Ning.,...&任建林.(2012).The Silencing of Pokemon Attenuates the Proliferation of Hepatocellular Carcinoma Cells In Vitro and In Vivo by Inhibiting the PI3K/Akt Pathway.http://dx.doi.org/10.1371/journal.pone.0051916.
MLA	Lin, Chan-Chan,et al."The Silencing of Pokemon Attenuates the Proliferation of Hepatocellular Carcinoma Cells In Vitro and In Vivo by Inhibiting the PI3K/Akt Pathway".http://dx.doi.org/10.1371/journal.pone.0051916 (2012).